New dogs in the dogma: Lrp4 and Tid1 in neuromuscular synapse formation.

Full Abstract

Two recent papers reported identification of a long-sought agrin coreceptor, Lrp4 (Kim et al. in Cell and Zhang et al. in Neuron). In this issue of Neuron, Linnoila et al. report the identification of a new player in the agrin-MuSK pathway, Tid1, which directly interacts with MuSK and is responsible for transducing signals from MuSK activation to AChR clustering, culminating in cross-linking to the subsynaptic cytoskeleton. These papers substantially reshape the agrin-MuSK-ACh hypothesis of neuromuscular synaptogenesis.

Author information

Author/s: Song, Yuanquan (Y); Balice-Gordon, Rita (R);

Affiliation: Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6074, USA.

Journal and publication information

Publication Type: Comment; Journal Article; Review

Journal: Neuron (Neuron), published in United States. (Language: eng)

Reference: 2008-Nov; vol 60 (issue 4) : pp 526-8

Dates: Created 2008/11/28; Completed 2009/01/16;

PMID: 19038209, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentOn: Neuron. 2008 Nov 26;60(4):625-41. (PMID: 19038220)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Agrin - metabolism
Animals
HSP40 Heat-Shock Proteins - metabolism
Humans
Mice
Neuromuscular Junction - embryology; metabolism; ultrastructure

Receptor Aggregation - physiology
Receptor Protein-Tyrosine Kinases - metabolism
Receptors, Cholinergic - metabolism
Receptors, LDL - metabolism
Signal Transduction - physiology
Synapses - metabolism; ultrastructure

Associated Chemicals: Agrin (0) ; Dnaja3 protein, mouse (0) ; HSP40 Heat-Shock Proteins (0) ; Lrp4 protein, mouse (0) ; Receptors, Cholinergic (0) ; Receptors, LDL (0) ; Receptor Protein-Tyrosine Kinases (EC 2.7.1.112) ; MuSK protein, mouse (EC 2.7.10.1)

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