Diagnostic value of CD163 in cutaneous spindle cell lesions.

Full Abstract

BACKGROUND: The histologic diagnosis of atypical fibroxanthoma (AFX) can sometimes be challenging. No specific marker exists to confirm the diagnosis other than excluding other entities. CD163 has been shown to have great specificity for tumors of monocyte/histiocyte lineage. In this study, we evaluated the diagnostic utility of CD163 in diagnosing AFX and in identifying skin lesions with histiocytic/dendritic derivation. METHODS: A total of 157 cases, including 14 AFXs, 5 spindle cell squamous cell carcinomas (SCCs), and 7 spindle cell/desmoplastic melanomas, along with other cutaneous spindle cell and histiocytic/fibrohistiocytic lesions, were stained with CD163. RESULTS: CD163 was expressed in 11 of 14 (79%) AFXs, with moderate to strong intensity. No staining was observed in cases of spindle cell SCC (0/5) and dermatofibrosarcoma protuberans (0/10). Rare spindle cell/desmoplastic melanomas (2/7) and cutaneous leiomyosarcomas (1/5) demonstrated positive staining. CD163 reactivity was seen in 24 of 29 of benign fibrous histiocytomas (BFHs), including 8 of 8 cellular fibrous histiocytomas and 6 of 9 epithelioid cell histiocytomas. The majority of cutaneous histiocytic lesions, including juvenile xanthogranuloma, Langerhans cell histiocytosis and Rosai-Dorfman disease, were positive for CD163. CONCLUSION: CD163 is a useful adjunct in distinguishing AFX from other malignant cutaneous spindle cell tumors and offers improved specificity in identifying cutaneous histiocytic/dendritic lesions.

Author information

Author/s: Pouryazdanparast, Pedram (P); Yu, Limin (L); Cutlan, Jonathan E (JE); Olsen, Stephen H (SH); Fullen, Douglas R (DR); Ma, Linglei (L);

Affiliation: Department of Pathology, University of Michigan, Ann Arbor, MI 48109-0602, USA.

Journal and publication information

Publication Type: Journal Article

Journal: Journal of cutaneous pathology (J Cutan Pathol), published in Denmark. (Language: eng)

Reference: 2009-Aug; vol 36 (issue 8) : pp 859-64

Dates: Created 2009/07/09; Completed 2009/09/22;

PMID: 19040468, status: MEDLINE (last retrieval date: 9/22/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Antigens, CD - biosynthesis
Antigens, Differentiation, Myelomonocytic - biosynthesis
Carcinoma, Squamous Cell - metabolism; pathology
Female
Fibrosarcoma - metabolism; pathology
Gene Expression Regulation, Neoplastic
Humans

Humans
Immunohistochemistry
Male
Melanoma - metabolism; pathology
Receptors, Cell Surface - biosynthesis
Skin Neoplasms - metabolism; pathology
Tumor Markers, Biological - biosynthesis

Associated Chemicals: Antigens, CD (0) ; Antigens, Differentiation, Myelomonocytic (0) ; CD163 antigen (0) ; Receptors, Cell Surface (0) ; Tumor Markers, Biological (0)

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