Research article summary (published 9 Nov 2008):

Nucleus accumbens acetylcholine and food intake: decreased muscarinic tone reduces feeding but not food-seeking.

Full Abstract

Separate groups of food-deprived rats were given 2h access to food after receiving bilateral nucleus accumbens infusions of the muscarinic antagonist scopolamine methyl bromide (at 0, 1.0, and 10.0 microg/side), the M2-preferring agonist oxotremorine sesquifumarate (Oxo-S; at 0, 1.0, or 10.0 microg/side) or the M2 antagonist AFDX-116 (at 0, 0.2, or 1.0 microg/side). Injections of scopolamine or Oxo-S, but not AFDX-116, reduced food consumption across the 2h. These experiments confirm a critical role for Acb acetylcholine in promoting food ingestion, and suggest that decreased acetylcholine tone at post-synaptic muscarinic receptors disrupts normal consummatory behavior.

Author information

Author/s: Pratt, Wayne E (WE); Blackstone, Kaitlin (K);

Affiliation: Department of Psychology, Wake Forest University, Winston-Salem, NC, USA. prattwe(-atsign-)wfu.edu

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Behavioural brain research (Behav Brain Res), published in Netherlands. (Language: eng)

Reference: 2009-Mar; vol 198 (issue 1) : pp 252-7

Dates: Created 2009/01/27; Completed 2009/03/30;

PMID: 19041901, status: MEDLINE (last retrieved date: 3/30/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Acetylcholine - physiology Animals Dose-Response Relationship, Drug Eating - drug effects; physiology Feeding Behavior - drug effects; physiology Male Microinjections Muscarinic Agonists - administration & dosage; pharmacology Muscarinic Antagonists - administration & dosage; pharmacology

Muscarinic Antagonists - administration & dosage; pharmacology N-Methylscopolamine - administration & dosage; pharmacology Nucleus Accumbens - drug effects; physiology Oxotremorine - administration & dosage; analogs & derivatives; pharmacology Parasympatholytics - administration & dosage; pharmacology Pirenzepine - administration & dosage; analogs & derivatives; pharmacology Rats Rats, Sprague-Dawley Receptors, Muscarinic - drug effects; physiology

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Muscarinic Agonists (0) ; Muscarinic Antagonists (0) ; Parasympatholytics (0) ; Receptors, Muscarinic (0) ; otenzepad (102394-31-0) ; N-Methylscopolamine (13265-10-6) ; oxotremorine sesquifumarate (17360-35-9) ; Pirenzepine (28797-61-7) ; Acetylcholine (51-84-3) ; Oxotremorine (70-22-4)

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