Research article summary (published 30 Nov 2008):

False negative result for amphetamines on the Triage Drug of Abuse panel? The cause of the unusual phenomenon with experimental analyses.

Full Abstract

On-site drug screening devices are widely used today for their simple test procedures and instantaneous results. Among other devices, a Triage Drug of Abuse panel is considered to be highly reliable for its high specificity and sensitivity of abused drugs. Although it is known that a false positive amphetamine (AMP) result may be obtained from the urine samples containing putrefactive amines or ephedrine-related compounds, no clinical false negative methamphetamine results have been reported to date. However, a false negative Triage result was obtained from the urine of a fatal methamphetamine poisoning victim taking Vegetamine tablets. Further experimental analyses revealed that the cross-reactivity of methamphetamine and chlorpromazine metabolites, including nor-2-chlorpromazine sulfoxide, was the cause for a false negative Triage reaction for AMP. Forensic scientists and clinicians must be aware of the limitations of on-site drug testing devices and the need for the confirmatory laboratory tests for the precise identification and quantification of drugs in suspicious intoxication cases, as also recommended by the manufacturers.

Author information

Author/s: Hikiji, Wakako (W); Kudo, Keiko (K); Sato, Shinji (S); Usumoto, Yosuke (Y); Tsuji, Akiko (A); Ikeda, Noriaki (N);

Affiliation: Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Journal and publication information

Publication Type: Case Reports; Journal Article

Journal: International journal of legal medicine (Int J Legal Med), published in Germany. (Language: eng)

Reference: 2009-May; vol 123 (issue 3) : pp 247-52

Dates: Created 2009/04/22; Completed 2009/08/03;

PMID: 19048267, status: MEDLINE (last retrieved date: 8/21/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Adult Amphetamine-Related Disorders - diagnosis; urine Animals Antipsychotic Agents - urine Autopsy - legislation & jurisprudence Chlorpromazine - analogs & derivatives; urine Cross Reactions Drug Combinations False Negative Reactions

False Negative Reactions Female Gas Chromatography-Mass Spectrometry Humans Male Methamphetamine - poisoning; urine Phenobarbital - urine Rats Substance Abuse Detection - instrumentation

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Antipsychotic Agents (0) ; Drug Combinations (0) ; vegetamin (0) ; Phenobarbital (50-06-6) ; Chlorpromazine (50-53-3) ; Methamphetamine (537-46-2) ; opromazine (969-99-3)

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