Skin-lightening effect of a polyphenol extract from Acerola (Malpighia emarginata DC.) fruit on UV-induced pigmentation.

Full Abstract

To investigate the physiological functions of polyphenols from acerola (Malpighia emarginata DC.) fruit, the effects on melanogenesis were studied. The crude polyphenol concentrated extract from acerola (C-AP) was used to examine the skin-lightening effect on brownish guinea pigs which had been subjected to controlled UVB irradiation. The results show that C-AP significantly lightened the UVB-irradiated skin pigmentation. Furthermore, treatment with C-AP reduced the content of melanin in B16 melanoma cells, suggesting that the in vivo skin-lightening effect of C-AP was due to the suppression of melanin biosynthesis in melanocytes. In addition, we found that C-AP could effectively inhibit mushroom tyrosinase activity, the main constituents responsible for this effect being thought to be such anthocyanins as cyanidin-3-alpha-O-rhamnoside (C3R) and pelargonidin-3-alpha-O-rhamnoside (P3R). This result indicates that the skin-lightening effect of C-AP can be partly attributed to the suppression of melanogenesis through the inhibition of tyrosinase activity in melanocytes. An oral ingestion of C-AP may therefore be efficacious for reducing UVB-induced hyper-pigmentation by inhibiting the tyrosinase in melanocytes.

Author information

Author/s: Hanamura, Takayuki (T); Uchida, Eriko (E); Aoki, Hitoshi (H);

Affiliation: Research and Development Division, Nichirei Foods Inc, Chiba-shi, Chiba, Japan. hanamurat(-atsign-)nichirei.co.jp

Journal and publication information

Publication Type: Journal Article

Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem), published in Japan. (Language: eng)

Reference: 2008-Dec; vol 72 (issue 12) : pp 3211-8

Dates: Created 2008/12/24; Completed 2009/02/11;

PMID: 19060403, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Administration, Oral
Agaricales - enzymology
Angiosperms - chemistry
Animals
Cell Line, Tumor
Epidermis - drug effects; metabolism; radiation effects
Female
Flavonoids - chemistry
Fruit - chemistry
Guinea Pigs

Guinea Pigs
Melanins - metabolism
Melanosomes - drug effects; metabolism; radiation effects
Mice
Monophenol Monooxygenase - antagonists & inhibitors
Phenols - chemistry
Plant Extracts - administration & dosage; pharmacology
Skin - cytology; drug effects; metabolism; radiation effects
Skin Pigmentation - drug effects; radiation effects
Ultraviolet Rays - adverse effects

Associated Chemicals: Flavonoids (0) ; Melanins (0) ; Phenols (0) ; Plant Extracts (0) ; polyphenols (0) ; Monophenol Monooxygenase (EC 1.14.18.1)

These are the highest related articles currently in the database: