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| Research article summary (published 29 Nov 2008): |
Relationship between post-traumatic stress disorder-like behavior and reduction of hippocampal 5-bromo-2'-deoxyuridine-positive cells after inescapable shock in rats.
Full Abstract
AIM: Inescapable shocks (IS) have been reported to reduce the number of 5-bromo-2'-deoxyuridine (BrdU)-positive cells in hippocampus. Antidepressants prevent this reduction, and the role of neurogenesis in depression is now suggested. It has been reported, however, that the number of BrdU-positive cells was not different between the rats that developed learned helplessness and those that did not. This suggests that reduction of neurogenesis does not constitute a primary etiology of depression. It has been previously shown that IS can cause various post-traumatic stress disorder (PTSD)-like behavioral changes in rats. The aim of the present was therefore to examined whether the reduction of BrdU-positive cells relates to any PTSD-like behavioral changes in this paradigm. METHODS: Rats were given either inescapable foot-shocks (IS) or not shocked (non-S) treatment in a shuttle box on day 1 and received BrdU injections once daily during the first week after IS/non-S treatment. On day 14, rats treated with IS and non-S were given an avoidance/escape test in the shuttle box and dorsal hippocampal SGZ were analyzed by BrdU immunohistochemistry. RESULTS: In accordance with previously reported results, IS loading resulted in fewer BrdU-positive cells in the hippocampal subgranular zone (SGZ). Furthermore, in the IS-treated group, the number of BrdU-positive cells in the hippocampal SGZ was negatively correlated at a significant level with several hyperactive behavioral parameters but not with hypoactive behavioral parameters. Earlier findings had indicated that chronic selective serotonin re-uptake inhibitor administration, which is known to increase hippocampal neurogenesis, restored the increase in hypervigilant/hyperarousal behavior but did not attenuate the increase in numbing/avoidance behavior. CONCLUSION: The regulatory mechanism responsible for the decreased proliferation and survival of cells in the hippocampus may be related to the pathogenic processes of hypervigilance/hyperarousal behaviors.
Author information
Author/s: Kikuchi, Akihito (A); Shimizu, Kunio (K); Nibuya, Masashi (M); Hiramoto, Takeshi (T); Kanda, Yasunari (Y); Tanaka, Teppei (T); Watanabe, Yasuhiro (Y); Takahashi, Yoshitomo (Y); Nomura, Soichiro (S);
Affiliation: Division of Behavioral Sciences, National Defense Medical College Research Institute, Tokyo, Japan.
Journal and publication information
Publication Type: Journal Article
Journal: Psychiatry and clinical neurosciences (Psychiatry Clin Neurosci), published in Australia. (Language: eng)
Reference: 2008-Dec; vol 62 (issue 6) : pp 713-20
Dates: Created 2008/12/10; Completed 2009/02/20;
PMID: 19068009, status: MEDLINE (last retrieval date: 3/9/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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