Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats.

Full Abstract

Cannabidiol (CBD) is a cannabinoid component from Cannabis sativa that does not induce psychotomimetic effects and possess anti-inflammatory properties. In the present study we tested the effects of CBD in a periodontitis experimental model in rats. We also investigated possible mechanisms underlying these effects. Periodontal disease was induced by a ligature placed around the mandible first molars of each animal. Male Wistar rats were divided into 3 groups: control animals; ligature-induced animals treated with vehicle and ligature-induced animals treated with CBD (5 mg/kg, daily). Thirty days after the induction of periodontal disease the animals were sacrificed and mandibles and gingival tissues removed for further analysis. Morphometrical analysis of alveolar bone loss demonstrated that CBD-treated animals presented a decreased alveolar bone loss and a lower expression of the activator of nuclear factor-kappaB ligand RANKL/RANK. Moreover, gingival tissues from the CBD-treated group showed decreased neutrophil migration (MPO assay) associated with lower interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha production. These results indicate that CBD may be useful to control bone resorption during progression of experimental periodontitis in rats.

Author information

Author/s: Napimoga, Marcelo H (MH); Benatti, Bruno B (BB); Lima, Flavia O (FO); Alves, Polyanna M (PM); Campos, Alline C (AC); Pena-Dos-Santos, Diego R (DR); Severino, Fernando P (FP); Cunha, Fernando Q (FQ); Guimarães, Francisco S (FS);

Affiliation: Laboratory of Molecular Biology, University of Uberaba, Brazil. marcelo.napimoga(-atsign-)uniube.br

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: International immunopharmacology (Int Immunopharmacol), published in Netherlands. (Language: eng)

Reference: 2009-Feb; vol 9 (issue 2) : pp 216-22

Dates: Created 2009/01/26; Completed 2009/04/30;

PMID: 19070683, status: MEDLINE (last retrieved date: 4/30/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Bone Resorption - drug therapy; etiology; pathology
Cannabidiol - therapeutic use
Cell Movement - drug effects; immunology
Cytokines - antagonists & inhibitors
Disease Models, Animal
Male

Male
Neutrophils - drug effects; immunology; metabolism
Periodontitis - complications; drug therapy; pathology
Peroxidase - immunology; metabolism
RANK Ligand - antagonists & inhibitors
Rats
Rats, Wistar
Receptor Activator of Nuclear Factor-kappa B - antagonists & inhibitors

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Anti-Inflammatory Agents, Non-Steroidal (0) ; Cytokines (0) ; RANK Ligand (0) ; Receptor Activator of Nuclear Factor-kappa B (0) ; Cannabidiol (13956-29-1) ; Peroxidase (EC 1.11.1.7)

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