60-year old woman with extra-axial frontal mass.

Full Abstract

We describe a 60 year-old woman presenting with visual loss of her left eye. No lymphadenopathies, fever, or weight loss were detected. Neuroimaging studies revealed an extra-axial mass along the posterior aspect of the left optic nerve. The mass was resected and showed xanthomatous histiocytes that were positive for CD-68, occasionally positive for S-100, and negative for CD-1. The lesion was diagnosed as Erdheim-Chester disease (ECD) affecting the CNS. The patient is under systemic evaluation in order to discover other ECD lesions. Microscopic findings and differential diagnoses are discussed.

Author information

Author/s: Arakaki, Naomi (N); Riudavets, Miguel A (MA); Cervio, Andrés (A); Ferreira, Marcelo (M); Sevlever, Gustavo (G);

Journal and publication information

Publication Type: Case Reports; Letter

Journal: Brain pathology (Zurich, Switzerland) (Brain Pathol), published in Switzerland. (Language: eng)

Reference: 2009-Jan; vol 19 (issue 1) : pp 157-60

Dates: Created 2008/12/16; Completed 2009/02/19;

PMID: 19076782, status: MEDLINE (last retrieval date: 3/9/2009, IMS Date: )

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Antigens, CD - analysis
Antigens, Differentiation, Myelomonocytic - analysis
Blindness - etiology
Diagnosis, Differential
Erdheim-Chester Disease - complications; diagnosis; metabolism
Female

Histiocytes - chemistry; pathology
Humans
Magnetic Resonance Imaging
Middle Aged
Optic Nerve Neoplasms - complications; diagnosis; metabolism
S100 Proteins - analysis

Associated Chemicals: Antigens, CD (0) ; Antigens, Differentiation, Myelomonocytic (0) ; CD68 antigen, human (0) ; S100 Proteins (0)

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