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| Research article summary (published 31 May 2009): |
Increased expression of TGFbeta type I receptor in brain tissues of patients with temporal lobe epilepsy.
Full Abstract
TbetaRs (transforming growth factor beta receptors) have recently been identified in animal experiments as being involved in the pathogenesis of epilepsy. The aim of the present study was to understand further the potential effects of TbetaRs in human epilepsy. Tissue samples of temporal neocortices from 30 patients with temporal lobe epilepsy were prepared for detecting TbetaR-I (type 1 TbetaR) protein expression using immunohistochemistry, immunofluorescence and Western blotting. We compared these tissues with histologically normal temporal lobes from controls. TbetaR-I immunoreactivity was increased in the patient group compared with controls using immunohistochemistry, and this finding was consistently observed with Western blot analysis. Immunofluorescence showed that TbetaR-I fluorescence stain mainly accumulated in the cytoplasm of astrocytes. In conclusion, our findings demonstrate that an up-regulation of TbetaR-I is present in patients with temporal lobe epilepsy.
Author information
Author/s: Lu, Yang (Y); Xue, Tao (T); Yuan, Jie (J); Li, Yuqin (Y); Wu, Yuan (Y); Xi, Zhiqin (Z); Xiao, Zheng (Z); Chen, Yangmei (Y); Wang, Xuefeng (X);
Affiliation: Department of Geriatric Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Journal and publication information
Publication Type: Journal Article
Journal: Clinical science (London, England : 1979) (Clin Sci (Lond)), published in England. (Language: eng)
Reference: 2009-Jul; vol 117 (issue 1) : pp 17-22
Dates: Created 2009/05/29; Completed 2009/07/31; Revised 2009/08/12;
PMID: 19086922, status: MEDLINE (last retrieved date: 8/21/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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Associated Chemicals: Receptors, Transforming Growth Factor beta (0) ; TGF-beta type I receptor (EC 2.7.1.11) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)Related articles
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