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| Research article summary (published 30 May 2009): |
Improving the damage accumulation in a biomechanical bone remodelling model.
Full Abstract
We extend, reformulate and analyse a phenomenological model for bone remodelling. The original macrobiomechanical model (MBM), proposed by Hazelwood et al. [J Biomech 2001; 34:299-308], couples a population equation for the cellular activities of the basic multicellular units (BMUs) in the bone and a rate equation to account for microdamage and repair. We propose to account for bone failure under severe overstressing by incorporating a Paris-like power-law damage accumulation term. The extended model agrees with the Hazelwood et al. predictions when the bone is under-stressed, and allows for suitably loaded bones to fail, in agreement with other MBM and experimental data regarding damage by fatigue. We numerically solve the extended model using a convergent algorithm and show that for unchanging loads, the stationary solution captures fully the model behaviour. We compute and analyse the stationary solutions. Our analysis helps guide additional extensions to this and other BMU activity based models.
Author information
Author/s: Restrepo, J M (JM); Choksi, R (R); Hyman, J M (JM); Jiang, Y (Y);
Affiliation: Department of Mathematics and Department of Physics, University of Arizona, Tucson, AZ, USA.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal: Computer methods in biomechanics and biomedical engineering (Comput Methods Biomech Biomed Engin), published in England. (Language: eng)
Reference: 2009-Jun; vol 12 (issue 3) : pp 341-52
Dates: Created 2009/04/27; Completed 2009/06/18;
PMID: 19089785, status: MEDLINE (last retrieval date: 6/18/2009, IMS Date: 18 Jun 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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