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| Research article summary (published 13 Dec 2009): |
Superimposed linear psoriasis: differential therapeutic response of linear and nonlinear lesions.
Full Abstract
Linear psoriasis is a very unusual clinical variation of psoriasis. Typical clinical features include early onset of erythematosquamous lesions along Blaschko's lines, ability to elicit psoriatic features, absence of pruritus and positive family history for psoriasis. Recently, the term 'superimposed linear psoriasis' was coined for cases with development of nonlinear psoriatic lesions at predilection sites in later life. We report a 19-year-old woman meeting all criteria for the diagnosis of superimposed linear psoriasis including typical histological features. Remarkably, treatment with topical steroids and dithranol cleared the psoriatic lesions on predilection sites whereas the linear lesions were resistant to topical therapy. Linear psoriatic lesions are believed to be caused by genetic alterations in early embryogenesis leading to loss of heterozygosity at a gene locus involved in the pathogenesis of psoriasis. Comparison of mosaic keratinocytes derived from linear lesions with wild-type keratinocytes from the same person may therefore allow identification of key regulatory genes.
Author information
Author/s: Seitz, C S (CS); Garbaraviciene, J (J); Bröcker, E-B (EB); Hamm, H (H);
Affiliation: Department of Dermatology, Venereology and Allergology, University of Würzburg, Würzburg, Germany.
Journal and publication information
Publication Type: Case Reports; Journal Article
Journal: Clinical and experimental dermatology (Clin Exp Dermatol), published in England. (Language: eng)
Reference: 2009-Jul; vol 34 (issue 5) : pp e177-9
Dates: Created 2009/06/10; Completed 2009/07/27;
PMID: 19094135, status: MEDLINE (last retrieval date: 8/20/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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