 |
| Research article summary (published 29 Nov 2008): |
|
Free Full Text! See links below |
Reduction of micronuclei in oral lichen planus supplemented with beta-carotene.
Full Abstract
An elevated frequency of micronucleated exfoliated cells (MEC) in atrophic and erosive oral lichen planus (OLP) has been reported. To evaluate the effects of supplemental beta-carotene (BC) on MEC frequency in OLP lesions, we performed an open trial in 20 patients with atrophic and/or erosive OLP. Each patient received 15 mg of BC four times daily for 3 months. The frequency of MEC in both lesions and adjacent normal mucosa in each patient was evaluated and compared before and after supplementation. Serum levels of BC and retinol were also determined. After BC supplementation, all patients had higher levels of serum BC and retinol. The MEC frequency in OLP lesions was significantly reduced (P < 0.01). No significant changes were seen in the MEC frequency in adjacent normal mucosa. BC supplementation thus significantly reduces MEC frequency in atrophic and erosive OLP.
Author information
Author/s: Buajeeb, Waranun (W); Kraivaphan, Petcharat (P); Amornchat, Cholticha (C); Suthamajariya, Kittisak (K);
Affiliation: Department of Oral Medicine, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. dtwbj(-atsign-)mahidol.ac.th
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal: Journal of oral science (J Oral Sci), published in Japan. (Language: eng)
Reference: 2008-Dec; vol 50 (issue 4) : pp 461-7
Dates: Created 2008/12/24; Completed 2009/05/07;
PMID: 19106475, status: MEDLINE (last retrieved date: 5/7/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article
(including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MeSH Headings (categories) shown below.
Note: Bold headings indicate primary MeSH headings or qualifiers.
Associated Chemicals: Vitamins (0) ; Vitamin A (11103-57-4) ; beta Carotene (7235-40-7)Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a larger map of 100+ related articles.