Mangifera indica extract (Vimang) impairs aversive memory without affecting open field behaviour or habituation in rats.

Full Abstract

Vimang is an aqueous extract of Mangifera indica L, used in Cuba for the treatment of immunopathological disorders. Increasing evidence from preclinical studies indicates that Vimang displays antioxidant, antiallergic, analgesic and antiinflammatory actions. The present study investigated the effects of systemic administration of Vimang on behavioural outcomes of neurological function in rats. A single oral administration of Vimang produced an impairment of short- and long-term retention of memory for aversive training when given either 1 h pretraining or immediately posttraining, but not 8 h posttraining. Vimang did not affect open field behaviour or habituation. The results indicate that Vimang might induce deficits of emotionally motivated memory without affecting nonassociative memory, locomotion, exploratory behaviour or anxiety. (c) 2008 John Wiley & Sons, Ltd.

Author information

Author/s: Preissler, Thales (T); Martins, Márcio Rodrigo (MR); Pardo-Andreu, Gilberto L (GL); Henriques, João Antônio Pêgas (JA); Quevedo, João (J); Delgado, Rene (R); Roesler, Rafael (R);

Affiliation: Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Phytotherapy research : PTR (Phytother Res), published in England. (Language: eng)

Reference: 2009-Jun; vol 23 (issue 6) : pp 859-62

Dates: Created 2009/05/27; Completed 2009/06/17;

PMID: 19107736, status: MEDLINE (last retrieval date: 6/17/2009, IMS Date: 17 Jun 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Avoidance Learning - drug effects
Behavior, Animal - drug effects
Habituation, Psychophysiologic - drug effects
Male
Mangifera - chemistry

Associated Chemicals: Mangifera indica extract (0) ; Plant Extracts (0)

This article has not been indexed for related articles as yet, however you can still use the live related article search links below.

See 100+ related articles.

See a large map of 100+ related articles.