Research article summary (published 29 Nov 2008):

Corticosterone regulates pERK1/2 map kinase in a chronic depression model.

Full Abstract

Neurotransmitter- or neurotrophin-regulated intracellular signaling in the hippocampus is hypothesized to contribute to depression and antidepressant (ADT) efficacy. Extracellular signal-regulated kinase 1/2 (ERK1/2) is downstream of several receptor types and regulates transcriptional activity of many targets; ERK1/2 may thereby influence mood and affect. Using a novel, ADT-sensitive depression model in mice, we show that prior corticosterone exposure decreases motivated behavior, sucrose consumption, and pERK1/2 in the dentate gyrus, but not in CA1/CA3. Notably, prefrontal cortical targets were also regulated. Our data suggest ADTs restore hippocampal pERK1/2 after stress-related insult, and potentially reveal a novel role for prefrontal neurotrophins in depressive-like symptomology.

Author information

Author/s: Gourley, Shannon L (SL); Wu, Florence J (FJ); Taylor, Jane R (JR);

Affiliation: Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut, USA.

Grants: MH025642 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci), published in United States. (Language: eng)

Reference: 2008-Dec; vol 1148 (issue ) : pp 509-14

Dates: Created 2009/01/05; Completed 2009/01/23;

PMID: 19120149, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Antidepressive Agents - therapeutic use Behavior, Animal - drug effects; physiology Brain-Derived Neurotrophic Factor - metabolism Conditioning, Operant Corticosterone - metabolism; pharmacology Depression - drug therapy; metabolism; physiopathology

Disease Models, Animal Hippocampus - anatomy & histology; metabolism MAP Kinase Signaling System - physiology Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism

Associated Chemicals: Antidepressive Agents (0) ; Brain-Derived Neurotrophic Factor (0) ; Corticosterone (50-22-6) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.1.37) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.1.37)

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