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Discovery of novel 2',3',4'-trihydroxy-2-phenylacetophenone derivatives as anti-gram-positive antibacterial agents.
Full Abstract
A number of 2',3',4'-trihydroxy-2-phenylacetophenone derivatives were synthesized and examined for growth inhibition of several kinds of bacteria. 2',3',4'-Trihydroxy-2-phenylacetophenone itself exhibited no antibacterial activity, but some of its derivatives showed various antibacterial activities depending on functional groups introduced on the 2-phenyl ring. Eighteen out of 24 compounds synthesized in this study appeared to possess antibacterial activities against at least two Gram-positive strains of Bacillus subtilis and Staphylococcus aureus, 2-(biphenyl-4-yl)-2',3',4'-trihydroxyacetophenone being the most active with LC(50) of 5.8 muM and 5.6 muM respectively. However, none of the synthesized compounds exhibited inhibitory effects on Gram-negative strains, such as Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, and Salmonella enterica, suggesting that anti-Gram-positive specificity of the antibacterial compounds.
Author information
Author/s: Goto, Hideyuki (H); Kumada, Yuji (Y); Ashida, Hitoshi (H); Yoshida, Ken-Ichi (K);
Affiliation: Institute for Environmental Sciences, University of Shizuoka.
Journal and publication information
Publication Type: Journal Article
Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem), published in Japan. (Language: eng)
Reference: 2009-Jan; vol 73 (issue 1) : pp 124-8
Dates: Created 2009/01/23; Completed 2009/04/01;
PMID: 19129641, status: MEDLINE (last retrieved date: 4/1/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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Associated Chemicals: Acetophenones (0) ; Anti-Bacterial Agents (0) ; acetophenone (98-86-2)Related articles
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