Integrated disease management improves one-year quality of life in primary care COPD patients: a controlled clinical trial.

Full Abstract

AIMD: To assess the long-term effectiveness of an integrated disease management (IDM) program (consisting of optimal medication, reactivation, education, and exacerbation management) in primary care patients with chronic obstructive pulmonary disease (COPD). METHOD: Controlled trial comparing the effects of IDM on quality of life--assessed by the St. George's Respiratory Questionnaire (SGRQ)--in primary care COPD patients. The minimal clinically important change on the SGRQ was accepted as being -4 points. Baseline and one year differences were compared using paired sample T-tests. The differential effects of an FEV1/FVC ratio <0.7 and dyspnoea as assessed by the Medical Research Council (MRC) Dyspnoea scale were investigated. RESULTS: The average age of subjects was 63 years, with an average post-bronchodilator FEV1 of 67% predicted, average FEV1/FVC ratio of 0.65, a mean of 35 pack-years smoking, and 63% were male. No significant differences existed between groups at baseline. After one year of IDM, SGRQ had improved by -4.6 points (95% CI, -7.2 to -2.0; p=0.001) in the intervention group, versus -0.7 points (95% CI, - 3.0 to 1.6; p=0.6) in the usual care group. In patients with an FEV1/FVC ratio <0.7, SGRQ improved by -5.9 points (95% CI, -9.6 to -2.2; p=0.002) in the IDM group, while in the usual care group SGRQ improved by -0.8 points (95% CI, -4.1 to 2.4; p=0.6). In patients with an MRC Dyspnoea score >2 and FEV1/FVC <0.7, SGRQ improved by -13.4 points (95% CI, -20.8 to -6.1; p=0.002) in the IDM group, versus -0.3 points (95% CI, -5.5 to 4.9; p=0.9) in the usual care group. CONCLUSION: In this study, IDM improved one-year quality of life in primary care COPD patients, compared to usual care. The improvement in SGRQ was both clinically relevant and statistically significant, and was greatest in patients with FEV1/FVC <0.7 and MRC Dyspnoea score >2.

Author information

Author/s: Chavannes, Niels H (NH); Grijsen, Marlous (M); van den Akker, Marjan (M); Schepers, Huub (H); Nijdam, Maddy (M); Tiep, Brian (B); Muris, Jean (J);

Affiliation: Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands. n.h.chavannes(-atsign-)lumc.nl

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

Journal: Primary care respiratory journal : journal of the General Practice Airways Group (Prim Care Respir J), published in England. (Language: eng)

Reference: 2009-Sep; vol 18 (issue 3) : pp 171-6

Dates: Created 2009/09/01; Completed 2009/11/16;

PMID: 19142557, status: MEDLINE (last retrieved date: 11/16/2009)

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