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| Research article summary (published 20 Nov 2008): |
Viewing a humorous film decreases IgE production by seminal B cells from patients with atopic eczema.
Full Abstract
OBJECTIVE: Sperms induced IgE production by seminal B cells from patients with atopic eczema via interaction of B cells with galectin-3 on sperms. We studied the effect of viewing a humorous film on IgE production by seminal B cells cultured with sperms. METHODS: Twenty-four male patients with atopic eczema viewed a humorous film (Modern Times, featuring Charlie Chaplin). Just before and immediately after viewing, semen was collected, and seminal B cells and sperms were purified. Seminal B cells were cultured with sperms and IgE production was measured, while expression of galectin-3 on sperms was assessed. RESULTS: After viewing the humorous film, IgE production by B cells cultured with sperms was significantly decreased. Moreover, expression of galectin-3 on sperms was reduced. CONCLUSION: Viewing a humorous film reduced galectin-3 expression on sperms, which in turn decreased IgE production by seminal B cells cultured with sperms. These results indicate that viewing a humorous film may be helpful for the study and treatment of local IgE production and allergy in the reproductive tract.
Author information
Author/s: Kimata, Hajime (H);
Affiliation: Department of Allergy, Moriguchi-Keijinkai Hospital, Moriguchi, Osaka, Japan. kimata-keijinkai(-atsign-)mkc.zap.ne.jp
Journal and publication information
Publication Type: Clinical Trial; Journal Article
Journal: Journal of psychosomatic research (J Psychosom Res), published in England. (Language: eng)
Reference: 2009-Feb; vol 66 (issue 2) : pp 173-5
Dates: Created 2009/01/21; Completed 2009/03/25;
PMID: 19154860, status: MEDLINE (last retrieval date: 3/25/2009, IMS Date: 25 Mar 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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