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| Research article summary (published 31 Jan 2009): |
The Bypassing the Blues treatment protocol: stepped collaborative care for treating post-CABG depression.
Full Abstract
OBJECTIVE: To present the design of the Bypassing the Blues (BtB) study to examine the impact of a collaborative care strategy for treating depression among patients with cardiac disease. Coronary artery bypass graft (CABG) surgery is one of the most common and costly medical procedures performed in the US. Up to half of post-CABG patients report depressive symptoms, and they are more likely to experience poorer health-related quality of life (HRQoL), worse functional status, continued chest pains, and higher risk of cardiovascular morbidity independent of cardiac status, medical comorbidity, and the extent of bypass surgery. METHODS: BtB was designed to enroll 450 post-CABG patients from eight Pittsburgh-area hospitals including: (1) 300 patients who expressed mood symptoms preceding discharge and at 2 weeks post hospitalization (Patient Health Questionnaire (PHQ-9) >or=10); and (2) 150 patients who served as nondepressed controls (PHQ-9 <5). Depressed patients were randomized to either an 8-month course of nurse-delivered telephone-based collaborative care supervised by a psychiatrist and primary care expert, or to their physicians' "usual care." The primary hypothesis will test whether the intervention can produce an effect size of >or=0.5 improvement in HRQoL at 8 months post CABG, as measured by the SF-36 Mental Component Summary score. Secondary hypotheses will examine the impact of our intervention on mood symptoms, cardiovascular morbidity, employment, health services utilization, and treatment costs. RESULTS: Not applicable. CONCLUSIONS: This effectiveness trial will provide crucial information on the impact of a widely generalizable evidence-based collaborative care strategy for treating depressed patients with cardiac disease.
Author information
Author/s: Rollman, Bruce L (BL); Belnap, Bea Herbeck (BH); LeMenager, Michelle S (MS); Mazumdar, Sati (S); Schulberg, Herbert C (HC); Reynolds, Charles F (CF);
Affiliation: Division of General Internal Medicine, Center for Research on Health Care, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. rollmanbl(-atsign-)upmc.edu
Grants: P30 MH71944 (Agency:NIMH NIH HHS) ; R01 HL70000 (Agency:NHLBI NIH HHS)
Journal and publication information
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
Journal: Psychosomatic medicine (Psychosom Med), published in United States. (Language: eng)
Reference: 2009-Feb; vol 71 (issue 2) : pp 217-30
Dates: Created 2009/02/16; Completed 2009/05/20; Revised 2009/06/19;
PMID: 19188529, status: MEDLINE (last retrieved date: 6/19/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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Associated Chemicals: Antidepressive Agents (0)Related articles
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