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| Research article summary (published 16 Dec 2009): |
Longitudinal evaluation of mycophenolic acid pharmacokinetics in pediatric kidney transplant recipients. The role of post-transplant clinical and therapeutic variables.
Full Abstract
This longitudinal study assessed the influence of post-transplant clinical and therapeutic variables in 50 kidney transplant recipients aged 2-19 yr receiving a triple immunosuppressive regimen consisting of cyclosporine microemulsion (CsA), steroids and MMF (300-400 mg/m(2) body surface area twice daily), the full pharmacokinetic profile (10 points) of which was investigated on post-transplant days 6, 30, 180 and 360. Total plasma MPA was measured by Enzyme Multiplied Immunoassay Technique. CsA therapeutic drug monitoring (TDM) was performed via C2 blood monitoring, while MPA TDM via C0. MPA Cmax, tmax, AUC0-12 and AUC0-4 pharmacokinetic profile changed significantly during the first post-transplant year. C0 was a poor predictor of the total MPA exposure [as measured by the area under the concentration-time curve AUC)], while a truncated AUC was a good surrogate of the 12-h profile (r = 0.91; p < 0.001) Graft function and cyclosporine therapy influenced MPA pharmacokinetics, as shown by the univariate and multivariate analyses. We conclude that because after transplantation MPA exposure varied over time, a strict TDM is advisable in the pediatric population.
Author information
Author/s: Ghio, Luciana (L); Ferraresso, Mariano (M); Zacchello, Graziella (G); Murer, Luisa (L); Ginevri, Fabrizio (F); Belingheri, Mirco (M); Peruzzi, Licia (L); Zanon, Franco (F); Perfumo, Francesco (F); Berardinelli, Luisa (L); Tirelli, Silvia (S); Dello Strologo, Luca (L); Fontana, Iris (I); Valente, Umberto (U); Cardillo, Massimo (M); Edefonti, Alberto (A);
Affiliation: Pediatric Nephrology Unit, Maggiore Policlinico Hospital, Mangiagalli and Regina Elena Foundation, IRCCS, Milan, Italy.
Journal and publication information
Publication Type: Evaluation Studies; Journal Article; Multicenter Study
Journal: Clinical transplantation (Clin Transplant), published in Denmark. (Language: eng)
Reference: 2009-Mar; vol 23 (issue 2) : pp 264-70
Dates: Created 2009/04/27; Completed 2009/07/30;
PMID: 19191807, status: MEDLINE (last retrieval date: 8/20/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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