Assessment of liver graft function and regeneration by galactosyl-human serum albumin (99mTc-GSA) liver scintigraphy in adult living-donor liver transplantation.

Full Abstract

BACKGROUND: In adult living-donor liver transplantation (LDLT), the assessment of the graft functional reserve is very important. We evaluated the graft functional reserve by technetium-99m-diethylenetriaminepenta-acetic acid-galactosyl-human serum albumin ((99m)Tc-GSA) liver scintigraphy. PATIENTS AND METHOD: From May 2003 to September 2006, (99m)Tc-GSA studies were performed in 27 adult recipients on two, four wk after LDLT, the receptor index [ratio of liver to heart-plus-liver radioactivity at 15 minutes (LHL15)] (LHL15) was calculated. Recipients were divided into two groups according to LHL15 on two wk after LDLT (group H; >0.935, group L; <0.935). Liver functional tests and recipients' background parameters were evaluated between the two groups. RESULT: Group L accompanied higher preoperative model for end-stage liver disease (MELD) score (p = 0.038), lower graft-recipient weight ratio (GRWR) (p = 0.032) and older donor age (p = 0.003) compared with group H. There was no significant difference in the graft regeneration rate between two groups. The three-yr cumulative survival rate was 76.1% in group L and 88.9% in group H. CONCLUSION: In LDLT, LHL15 has the potential to assess the graft function and predict the recipients' outcome. Graft function after LDLT may be related closely to the pretransplant MELD score, GRWR, and donor age.

Author information

Author/s: Iida, Taku (T); Isaji, Shuji (S); Yagi, Shintaro (S); Hori, Tomohide (T); Taniguchi, Kentaro (K); Ohsawa, Ichiro (I); Mizuno, Shugo (S); Usui, Masanobu (M); Sakurai, Hiroyuki (H); Yamagiwa, Kentaro (K); Yamakado, Kouichiro (K); Uemoto, Shinji (S);

Affiliation: Division of Hepato-Biliary Pancreatic Surgery, Mie University, Tsu city, Mie, Japan. itaku(-atsign-)kuhp.kyoto-u.ac.jp

Journal and publication information

Publication Type: Journal Article

Journal: Clinical transplantation (Clin Transplant), published in Denmark. (Language: eng)

Reference: 2009-Mar; vol 23 (issue 2) : pp 271-7

Dates: Created 2009/04/27; Completed 2009/07/30;

PMID: 19191810, status: MEDLINE (last retrieval date: 8/20/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Aged
Female
Graft Survival
Humans
Liver - radiography; radionuclide imaging
Liver Function Tests
Liver Regeneration - physiology
Liver Transplantation - physiology

Living Donors
Male
Middle Aged
Radionuclide Imaging
Radiopharmaceuticals - diagnostic use
Survival Rate
Technetium Tc 99m Aggregated Albumin - diagnostic use
Technetium Tc 99m Pentetate - diagnostic use
Tomography, Emission-Computed, Single-Photon
Young Adult

Associated Chemicals: Radiopharmaceuticals (0) ; Technetium Tc 99m Aggregated Albumin (0) ; technetium Tc 99m DTPA-galactosyl-human serum albumin (0) ; Technetium Tc 99m Pentetate (65454-61-7)

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