 |
| Research article summary (published 14 Dec 2009): |
The influence of chronic periodontitis on serum TNF-alpha, IL-6 and hs-CRP concentrations, and function of graft and survival of kidney transplant recipients.
Full Abstract
OBJECTIVE: The aim of the study is to analyze whether chronic periodontitis (CP) influences serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and high-sensitivity C-reactive protein (hs-CRP) concentrations in renal transplant recipients and patients or graft survival. BACKGROUND: CP is associated both with higher serum concentrations of cytokines and CRP and high cardiovascular risk. METHODS: One hundred and seventeen patients with a transplanted kidney (Tx) were divided according to the Community Periodontal Index of Treatment Needs (CPITN) into two subgroups: TxP+: severe CP (CPITN 3-4) and TxP-: no or moderate CP (CPITN 0-2). The control group (C) consisted of 36 subjects with no kidney disease and with no or moderate CP (CPITN 0-2). RESULTS: hs-CRP concentration was higher in TxP+ than in TxP- patients [2.0 mg/L (0.7-4.4) vs. 0.9 mg/L (0.3-1.9), p = 0.006]. There were no differences in serum TNF-alpha and IL-6 between TxP+ and TxP-. Significant positive correlation between CPITN score and hs-CRP concentration was found both in Tx and C. The hazard ratio of death was 7.17 (1.4-76.4) for TxP+ patients. CP status did not increase the risk of graft loss or doubling of serum creatinine. CONCLUSIONS: Severe CP is associated with increased serum hs-CRP concentration in patients after kidney transplantation. Severe periodontitis seems to increase the risk of patients' death after kidney transplantation.
Author information
Author/s: Blach, Anna (A); Franek, Edward (E); Witula, Artur (A); Kolonko, Aureliusz (A); Chudek, Jerzy (J); Drugacz, Jan (J); Wiecek, Andrzej (A);
Affiliation: Department of Internal Diseases and Rheumatology, Silesian University School of Medicine, Katowice, Poland.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Clinical transplantation (Clin Transplant), published in Denmark. (Language: eng)
Reference: 2009-Mar; vol 23 (issue 2) : pp 213-9
Dates: Created 2009/04/27; Completed 2009/07/30;
PMID: 19191811, status: MEDLINE (last retrieval date: 8/20/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article
(including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.