Nandrolone decanoate administration dose-dependently affects the density of kappa opioid peptide receptors in the rat brain determined by autoradiography.

Full Abstract

The kappa opioid receptor ligand [(3)H]CI-977 was used to autoradiographically determine the density of kappa opioid receptors in the male rat brain following chronic treatment with the anabolic androgenic steroid nandrolone decanoate at two different doses. As compared to controls, significantly lower densities of the kappa opioid receptor were encountered after two weeks of high dose nandrolone decanoate (15 mg/kg) in the nucleus accumbens shell (16%), lateral hypothalamic area (36%), ventromedial hypothalamic nucleus (37%), dorsomedial hypothalamic nucleus (49%), central amygdaloid nucleus, capsular part (28%), lateral globus pallidus (35%) and in the stria terminalis (24%). Furthermore, an up-regulation of the receptor level was observed in the caudate putamen (18%) and in the dorsal endopiriform nucleus (23%). These alterations in the kappa opioid receptor expression are possibly attributed to a previously observed pronounced impact of nandrolone decanoate on the dynorphinergic system and could also include involvement of the dopaminergic reward system.

Author information

Author/s: Magnusson, K (K); Birgner, C (C); Bergström, L (L); Nyberg, F (F); Hallberg, M (M);

Affiliation: Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, Uppsala, Sweden. Kristina.Magnusson(-atsign-)farmbio.uu.se

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuropeptides (Neuropeptides), published in Scotland. (Language: eng)

Reference: 2009-Apr; vol 43 (issue 2) : pp 105-11

Dates: Created 2009/03/30; Completed 2009/08/19;

PMID: 19201466, status: MEDLINE (last retrieval date: 8/21/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Dynorphins - metabolism
Male
Nandrolone - administration & dosage; analogs & derivatives; pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Opioid, kappa - biosynthesis

Associated Chemicals: Anabolic Agents (0) ; Receptors, Opioid, kappa (0) ; nandrolone decanoate (360-70-3) ; Nandrolone (434-22-0) ; Dynorphins (74913-18-1)

These are the highest related articles currently in the database: