Evaluation of transcutaneous CO2 responses following acute changes in PaCO2 in healthy subjects.

Full Abstract

BACKGROUND AND OBJECTIVE: Transcutaneous blood gas-monitoring systems with miniaturized SpO(2) (peripheral blood oxygen saturation)/PCO(2) combined sensors (TOSCATM) have been widely used. There are no reports of the inter- and intra-individual variability in transcutaneous measurements of PaCO(2) (PtcCO(2)) in response to acute progressive changes in PaCO(2). This study examined inter- and intra-individual variability of PtcCO(2) measurements under semi-steady-state conditions, and characterized the behaviour of PtcCO(2) in response to acute progressive changes in PaCO(2). METHODS: Subjects breathed mixed gases through a mouthpiece connected to an automatic arterial blood gas controller. Using end-tidal PCO(2) and PO(2) as guides, PaCO(2) was controlled to increase and/or decrease between baseline and > or = 60 mm Hg, in a stepwise (n = 9) or progressive fashion (n = 6). Arterial blood was sampled when needed. RESULTS: Intra-individual correlation coefficients between PtcCO(2) and PaCO(2) were excellent in all subjects (0.971-0.989); however, the slope of the regression line varied among subjects (1.040-1.335). Bias and limits of agreement (+/- 2 SD from bias) between PtcCO(2) and PaCO(2) were -1.8 mm Hg and -7.7 to 4.1 mm Hg. Changes in PtcCO(2) in response to acute progressive changes in PaCO(2) also varied among subjects. CONCLUSION: The PtcCO(2) measurement system allows reliable estimation of PaCO(2) in a given subject. However, caution is needed when comparing absolute values between subjects or when acute changes in PaCO(2) occur.

Author information

Author/s: Fuke, Satoshi (S); Miyamoto, Kenji (K); Ohira, Hiroshi (H); Ohira, Megumi (M); Odajima, Nao (N); Nishimura, Masaharu (M);

Affiliation: First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

Journal and publication information

Publication Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't

Journal: Respirology (Carlton, Vic.) (Respirology), published in Australia. (Language: eng)

Reference: 2009-Apr; vol 14 (issue 3) : pp 436-42

Dates: Created 2009/04/03; Completed 2009/07/09;

PMID: 19210656, status: MEDLINE (last retrieval date: 7/24/2009, IMS Date: )

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