Research article summary (published 30 Aug 2009):

Vulnerability to depression: what is the role of stress genes in gene x environment interaction?

Full Abstract

Vulnerability to depression has been linked to the interaction of genetic predisposition with stressful life events. This review considers the associations between serotonergic and hypothalamic-pituitary-adrenal (HPA) systems. We follow the standpoint of a previous Editorial Review (Bhagwagar & Cowen, Psychological Medicine 2008, 38, 307-313) and consider another possible mechanism of vulnerability to depressive disorder, that is we suggest that the gene x environment interaction involves complex participation of serotonergic genes modulating response to stress through the HPA system.

Author information

Author/s: El Hage, W (W); Powell, J F (JF); Surguladze, S A (SA);

Journal and publication information

Publication Type: Editorial; Research Support, Non-U.S. Gov't; Review

Journal: Psychological medicine (Psychol Med), published in England. (Language: eng)

Reference: 2009-Sep; vol 39 (issue 9) : pp 1407-11

Dates: Created 2009/08/06; Completed 2009/10/20;

PMID: 19215634, status: MEDLINE (last retrieval date: 10/20/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Alleles Amygdala - physiopathology Arousal - genetics; physiology Depressive Disorder, Major - genetics; physiopathology; psychology Epistasis, Genetic - genetics Gene Expression Regulation - genetics Genetic Predisposition to Disease - genetics Gyrus Cinguli - physiopathology Humans

Hypothalamo-Hypophyseal System - physiopathology Life Change Events Phenotype Pituitary-Adrenal System - physiopathology Polymorphism, Genetic - genetics Receptors, Glucocorticoid - genetics Receptors, Mineralocorticoid - genetics Serotonin Plasma Membrane Transport Proteins - genetics Social Environment

Associated Chemicals: Receptors, Glucocorticoid (0) ; Receptors, Mineralocorticoid (0) ; SLC6A4 protein, human (0) ; Serotonin Plasma Membrane Transport Proteins (0)

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