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| Research article summary (published 9 Feb 2009): |
Changes in plasma and tissue amino acid levels in an animal model of complex fatigue.
Full Abstract
OBJECTIVE: Fatigue can be classified as physical or mental, depending on its cause. In physical fatigue, changes in the plasma levels of some amino acids have been reported. However, complex fatigue, which is experienced in daily life, is a combination of physical and mental fatigue. We aimed to identify changes in amino acid levels in the plasma, skeletal muscle, liver, and brain in an animal model of complex fatigue. METHODS: Rats were kept in a cage filled with water to a height of 2.2 cm for 5 d. Because rats showed a reduction of body weight when the model was developed, we also included a food-restricted group showing a similar profile in weight reduction as the water-immersed rats. A non-treated control group was also included. RESULTS: Results indicated that levels of branched-chain amino acids (valine, leucine, and isoleucine) were increased in plasma (valine, leucine, and isoleucine; P < 0.01), skeletal muscle (valine, leucine, and isoleucine; P < 0.01), the liver (valine; P < 0.05), and brain (isoleucine; P < 0.05), whereas a reduction in other amino acid levels (total amino acids and glutamine in the plasma, skeletal muscle, and liver; and phenylalanine, tyrosine, arginine, and threonine in the brain; P < 0.01) was seen in animals with complex fatigue. CONCLUSION: Complex fatigue may bring about systemic changes in amino acid metabolism in multiple organs.
Author information
Author/s: Jin, Guanghua (G); Kataoka, Yosky (Y); Tanaka, Masaaki (M); Mizuma, Hiroshi (H); Nozaki, Satoshi (S); Tahara, Tsuyoshi (T); Mizuno, Kei (K); Yamato, Masanori (M); Watanabe, Yasuyoshi (Y);
Affiliation: Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Nutrition (Burbank, Los Angeles County, Calif.) (Nutrition), published in United States. (Language: eng)
Reference: 2009-May; vol 25 (issue 5) : pp 597-607
Dates: Created 2009/04/03; Completed 2009/06/25;
PMID: 19216057, status: MEDLINE (last retrieval date: 6/25/2009, IMS Date: 25 Jun 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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