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| Research article summary (published 29 Sep 2009): |
Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor.
Full Abstract
The p75 neurotrophin receptor has been implicated in the regulation of multiple cellular functions that differ depending on the cell context. We have observed that p75(NTR) is strongly induced on astrocytes as well as neurons in the hippocampal CA3 region after seizures; however, the function of this receptor on these glial cells has not been defined. We have employed a primary culture system to investigate the effects of neurotrophins on astrocytes. Treatment of hippocampal astrocytes with nerve growth factor (NGF) caused a reduction in cell number, but did not elicit an apoptotic response, in contrast to hippocampal neurons. Instead, activation of p75(NTR) by NGF attenuated proliferation induced by mitogens such as EGF or serum. These studies demonstrate the cell type specificity of neurotrophin functions in the brain. (c) 2009 Wiley-Liss, Inc.
Author information
Author/s: Cragnolini, Andrea B (AB); Huang, Yangyang (Y); Gokina, Pradeepa (P); Friedman, Wilma J (WJ);
Affiliation: Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA.
Grants: NS045556 (Agency:NINDS NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal: Glia (Glia), published in United States. (Language: eng)
Reference: 2009-Oct; vol 57 (issue 13) : pp 1386-92
Dates: Created 2009/08/31; Completed 2009/10/30;
PMID: 19229990, status: MEDLINE (last retrieval date: 10/30/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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