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| Research article summary (published 30 Jan 2009): |
Modification of platelet shape change parameter by modified phospholipids in oxidized LDL.
Full Abstract
BACKGROUND: It is believed that the oxidatively modified lipoproteins play a critical role in activating platelets and is a contributing factor in the etiology of a number of cardiovascular-related diseases. OBJECTIVE: Identify the active component(s) of oxidized LDL that initiated shape change in plasma-free human platelets prepared by a gel filtration method Material and Method: Shape change parameter of platelets was monitored following exposure platelets to LDL, copper sulfate-oxidized LDL, and different types of lipids extracted of the corresponding LDL. RESULTS: Oxidized LDL, but not native LDL, increased the shape-change parameter in a concentration-dependent manner Specifically, phosphatidyl serine from oxidized LDL was responsible for this effect. CONCLUSION: Oxidized phospholipids generated during the oxidative modification of LDL are likely to be the active components responsible for changes in platelet function.
Author information
Author/s: Sutipornpalangkul, Werasak (W); Unchen, Supeenun (S); Sanvarinda, Yupin (Y); Chantharaksri, Udom (U);
Affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. tewsv(-atsign-)mahidol.ac.th
Journal and publication information
Publication Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't
Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai), published in Thailand. (Language: eng)
Reference: 2009-Feb; vol 92 (issue 2) : pp 229-35
Dates: Created 2009/03/03; Completed 2009/03/31;
PMID: 19253799, status: MEDLINE (last retrieved date: 3/31/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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Associated Chemicals: Lipoproteins, LDL (0) ; oxidized low density lipoprotein (0)Related articles
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