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| Research article summary (published 27 Feb 2009): |
Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers.
Full Abstract
The authors investigated the effect of herbal medicine Schisandra chinensis extract (SchE) and Ginkgo biloba extract (GBE) on the oral pharmacokinetics of P-glycoprotein substrate talinolol in humans. Twelve healthy male volunteers took a single 100-mg oral dose of talinolol either alone or after pretreatment with 300 mg SchE twice daily or with 120 mg GBE three times daily for 14 days. On day 14, a single 100-mg oral dose of talinolol was administered. Plasma concentrations of talinolol from zero to 24 h were measured by high-performance liquid chromatography. SchE increased the area under the curve (AUC)(0-24) of talinolol by 47% (90% confidence interval (CI), 18-84%; p = 0.010), and GBE by 21% (90% CI = 11-32%; p = 0.002). The C(max) of talinolol increased by 51% (90% CI = 21-89%; p = 0.007) with SchE treatment and by 33% (90% CI = 18-51%; p = 0.002) with GBE treatment, respectively. The t(1/2) of talinolol increased by 7% (90% CI = -4% to 19%; p = 0.320) with SchE treatment and by 11% (90% CI = -12% to 38%; p = 0.436) with GBE treatment, respectively. The results suggest that both SchE and GBE significantly inhibited P-glycoprotein in humans. Patients receiving either SchE or GBE may require dose adjustments when treated with drugs primarily transported by P-glycoprotein.
Author information
Author/s: Fan, L (L); Mao, X-Q (XQ); Tao, G-Y (GY); Wang, G (G); Jiang, F (F); Chen, Y (Y); Li, Q (Q); Zhang, W (W); Lei, H-P (HP); Hu, D-L (DL); Huang, Y-F (YF); Wang, D (D); Zhou, H-H (HH);
Affiliation: Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, P. R. China.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Xenobiotica; the fate of foreign compounds in biological systems (Xenobiotica), published in England. (Language: eng)
Reference: 2009-Mar; vol 39 (issue 3) : pp 249-54
Dates: Created 2009/03/12; Completed 2009/06/01;
PMID: 19280523, status: MEDLINE (last retrieval date: 6/1/2009, IMS Date: 01 Jun 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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