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| Research article summary (published 10 Mar 2009): |
[Empirical evidence for the use of anticonvulsants in personality disorders]
(Evidenz für den Einsatz von Antikonvulsiva bei Persönlichkeitsstörungen.)
Full Abstract
OBJECTIVE: There is a common practice of polypharmacy and an increased use of mood stabilizers in personality disorders (PD). This paper reviews all randomized controlled trials (RCTs) of anticonvulsants to evaluate the evidence base supporting their use in treatment of PD. METHODS: German and English language literature cited in Medline and published between 1970 and 2008 was searched using the following terms: Borderline/personality disorder, anticonvulsant, mood stabilizer, carbamazepine, felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, phenytoine, pregabalin, tiagabine, topiramate, and valproate. RESULTS: Twelve RCTs were identified which included anticonvulsants in treatment of personality disorders. The anticonvulsants valproate and topiramate appeared to have the most empirical support for having a favorable effect on symptoms of borderline personality disorder. Evidence for the use of other anticonvulsants in patients with PD is sparse. CONCLUSIONS: Valproate and topiramate, probably also lamotrigine, carbamazepine, and oxcarbazepine as well, were useful in treating symptoms of affective dysregulation and impulsive aggression in PD. However, further RCTs of anticonvulsants are greatly needed as clinical use of these agents has risen without sufficient evidence supporting their efficacy and safety in personality disorders.
Author information
Author/s: Sieberer, M (M); Emrich, H M (HM);
Affiliation: Zentrum Psychologische Medizin, Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie, Medizinische Hochschule Hannover. Sieberer.Marcel(-atsign-)mh-hannover.de
Journal and publication information
Publication Type: English Abstract; Journal Article; Review
Journal: Fortschritte der Neurologie-Psychiatrie (Fortschr Neurol Psychiatr), published in Germany. (Language: ger)
Reference: 2009-Mar; vol 77 (issue 3) : pp 133-8
Dates: Created 2009/03/13; Completed 2009/06/26;
PMID: 19283647, status: MEDLINE (last retrieval date: 6/26/2009, IMS Date: 26 Jun 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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