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| Research article summary (published 10 Mar 2009): |
Lesion mapping of cognitive abilities linked to intelligence.
Full Abstract
The Wechsler Adult Intelligence Scale (WAIS) assesses a wide range of cognitive abilities and impairments. Factor analyses have documented four underlying indices that jointly comprise intelligence as assessed with the WAIS: verbal comprehension (VCI), perceptual organization (POI), working memory (WMI), and processing speed (PSI). We used nonparametric voxel-based lesion-symptom mapping in 241 patients with focal brain damage to investigate their neural underpinnings. Statistically significant lesion-deficit relationships were found in left inferior frontal cortex for VCI, in left frontal and parietal cortex for WMI, and in right parietal cortex for POI. There was no reliable single localization for PSI. Statistical power maps and cross-validation analyses quantified specificity and sensitivity of the index scores in predicting lesion locations. Our findings provide comprehensive lesion maps of intelligence factors, and make specific recommendations for interpretation and application of the WAIS to the study of intelligence in health and disease.
Author information
Author/s: Gläscher, Jan (J); Tranel, Daniel (D); Paul, Lynn K (LK); Rudrauf, David (D); Rorden, Chris (C); Hornaday, Amanda (A); Grabowski, Thomas (T); Damasio, Hanna (H); Adolphs, Ralph (R);
Affiliation: Division of Humanities and Social Sciences, Caltech, Pasadena, CA 91125, USA.
Grants: P01 NS 19632 (Agency:NINDS NIH HHS) ; R01 DA 022549 (Agency:NIDA NIH HHS) ; R01 NS 054266 (Agency:NINDS NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal: Neuron (Neuron), published in United States. (Language: eng)
Reference: 2009-Mar; vol 61 (issue 5) : pp 681-91
Dates: Created 2009/03/16; Completed 2009/04/01; Revised 2009/08/19;
PMID: 19285465, status: MEDLINE (last retrieval date: 8/21/2009, IMS Date: 21 Aug 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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