Research article summary (published 11 Mar 2009):

Decreased inflammation and augmented expression of trophic factors correlate with MOG-induced neuroprotection of the injured nigrostriatal system in the murine MPTP model of Parkinson's disease.

Full Abstract

The response of the immune system during injury of the central nervous system may play a role in protecting neurons. We have previously reported that immunization with MOG 35-55 prior to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced injury of the dopaminergic system promotes less dopamine depletion and less dopaminergic damage of neurons in mice. In this study, we evaluate the influence of MOG immunization on the inflammatory reaction that occurs at the place of injury. C57Bl male mice, 2 and 12 months old, received i.p. injections of MPTP (40 mg/kg) and some groups animals also received an additional injection with myelin oligodendrocyte glycoprotein (MOG) 35-55 in CFA 6 days before MPTP administration. MPTP caused a common inflammatory reaction characterized by microglial activation, infiltration of T cells into the substantia nigra and striatum and increased expression of mRNA encoding pro-inflammatory cytokines (IL-1 beta, TNFalpha, INF gamma) and trophic factors (TGFbeta, GDNF). MOG immunization prior to MPTP administration significantly diminished the microglial reaction and reduced the levels of infiltrating CD8+ lymphocytes. The number of CD4+ T cells remained at the same level as in the MPTP group. Expression of pro-inflammatory cytokines was diminished. The mRNA expression of GDNF was significantly higher in the MOG pretreated mice relative to the MPTP group, both in the 2 month old and 12 month old groups. Since MOG immunization prior to MPTP intoxication appears to prevent nigrostriatal injury, the observed decrease of inflammation and increase of GDNF mRNA expression in the injured areas might represent one of the mechanisms of observed neuroprotection.

Author information

Author/s: Kurkowska-Jastrzebska, I (I); Balkowiec-Iskra, E (E); Ciesielska, A (A); Joniec, I (I); Cudna, A (A); Zaremba, M M (MM); Czlonkowski, A (A); Czlonkowska, A (A);

Affiliation: 2nd Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, Warsaw, Poland. kurkowsk(-atsign-)ipin.edu.pl

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: International immunopharmacology (Int Immunopharmacol), published in Netherlands. (Language: eng)

Reference: 2009-Jun; vol 9 (issue 6) : pp 781-91

Dates: Created 2009/05/04; Completed 2009/08/17;

PMID: 19286483, status: MEDLINE (last retrieved date: 8/21/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Animals Brain - drug effects; immunology; metabolism; pathology CD4-Positive T-Lymphocytes - drug effects; immunology; metabolism CD8-Positive T-Lymphocytes - drug effects; immunology; metabolism Cytokines - drug effects; immunology; metabolism Disease Models, Animal Glycoproteins - immunology; metabolism

Glycoproteins - immunology; metabolism Inflammation - immunology; metabolism MPTP Poisoning - immunology; metabolism Male Mice Mice, Inbred C57BL Neurons - drug effects; immunology; metabolism Peptide Fragments - immunology; metabolism

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Cytokines (0) ; Glycoproteins (0) ; Peptide Fragments (0) ; myelin oligodendrocyte glycoprotein (35-55) (0) ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (28289-54-5)

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