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| Research article summary (published 30 Dec 2008): |
Comparison of iodixanol and iohexol in patients undergoing intravenous pyelography: a prospective controlled study.
Full Abstract
BACKGROUND: Nephropathy associated with contrast medium exposure is a well-known complication of IVP. However, it is uncertain whether iso-osmolar non-iodinated contrast medium (iodixanol) is less nephrotoxic than low-osmolar contrast medium (iohexol). MATERIALS AND METHODS: In this single-center, double-blind, prospective study, 50 patients undergoing IVP were randomized into two groups receiving different contrast medium: iodixanol and iohexol. Patients in high risk for contrast nephropathy were included, 28 with renal insufficiency and 19 with diabetes mellitus. We compared the nephrotoxic effect (contrast nephropathy), complement and cytokines profile between the iodixanol and iohexol groups. The mean volume of contrast medium in each IVP procedure was 0.8 mL/kg. RESULTS: The incidence of contrast nephropathy was 4 percent among all patients (one iodixanol and one iohexol). We found no significant differences in contrast nephropathy and allergic reactions between the two groups. There was no significant difference in cytokine profiles in both groups (p > 0.05).The incidence of allergic reaction was 16 percent among all patients. Twelve percent (3/25) had late reaction after iohexol exposure compared to four percent (2/25) with iodixanol (p = 1.0). One patient had severe skin rash due to late adverse reaction after iodixanol. No mortality was found. CONCLUSIONS: New iodixanol and iohexol contrast medium for routine IVP examination are safe and have low nephrotoxicity profile, especially in elderly or high-risk patients. Iodixanol contrast medium has an increased risk to induce severe late adverse reaction compared to iohexol. Allergic reaction may be the main adverse effect after contrast medium infusion.
Author information
Author/s: Chuang, Feng-Rong (FR); Chen, Te-Chuan (TC); Wang, I-Kuan (IK); Chuang, Chung-Hua (CH); Chang, Hsueh-Wen (HW); Ting-Yu Chiou, Terry (T); Cheng, Yu-Fan (YF); Lee, Wei-Ching (WC); Chen, Wen-Chieh (WC); Yang, Kuender-D (KD); Lee, Chih-Hsiung (CH);
Affiliation: Division of Nephrology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan.
Journal and publication information
Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial
Journal: Renal failure (Ren Fail), published in United States. (Language: eng)
Reference: 2009-; vol 31 (issue 3) : pp 181-8
Dates: Created 2009/03/16; Completed 2009/05/18;
PMID: 19288321, status: MEDLINE (last retrieved date: 5/18/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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Associated Chemicals: Contrast Media (0) ; Cytokines (0) ; Triiodobenzoic Acids (0) ; Creatinine (60-27-5) ; Iohexol (66108-95-0) ; iodixanol (92339-11-2)Related articles
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