Research article summary (published 30 Jul 2009):

Stimulant treatment reduces lapses in attention among children with ADHD: the effects of methylphenidate on intra-individual response time distributions.

Full Abstract

Recent research has suggested that intra-individual variability in reaction time (RT) distributions of children with ADHD is characterized by a particularly large rightward skew that may reflect lapses in attention. The purpose of the study was to provide the first randomized, placebo-controlled test of the effects of the stimulant methylphenidate (MPH) on this tail and other RT distribution characteristics. Participants were 49 9- to 12-year-old children with ADHD. Children participated in a 3-day double-blind, placebo-controlled medication assessment during which they received long-acting MPH (Concerta), with the nearest equivalents of 0.3 and 0.6 mg/kg t.i.d. immediate-release MPH. Children completed a simple two-choice speeded discrimination task on and off of medication. Mode RT and deviation from the mode were used to examine the peak and skew, respectively, of RT distributions. MPH significantly reduced the peak and skew of RT distributions. Importantly, the two medication effects were uncorrelated suggesting that MPH works to improve both the speed and variability in responding. The improvement in variability with stimulant treatment is interpreted as a reduction in lapses in attention. This, in turn, may reflect stimulant enhancement of self-regulatory processes theorized to be at the core of ADHD.

Author information

Author/s: Spencer, Sarah V (SV); Hawk, Larry W (LW); Richards, Jerry B (JB); Shiels, Keri (K); Pelham, William E (WE); Waxmonsky, James G (JG);

Affiliation: Department of Psychology, University at Buffalo, SUNY, Park Hall, Box 604110, Buffalo, NY 14260-4110, USA.

Grants: MH069434 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural

Journal: Journal of abnormal child psychology (J Abnorm Child Psychol), published in United States. (Language: eng)

Reference: 2009-Aug; vol 37 (issue 6) : pp 805-16

Dates: Created 2009/07/10; Completed 2009/10/02;

PMID: 19291387, status: MEDLINE (last retrieval date: 10/2/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Attention - drug effects Attention Deficit Disorder with Hyperactivity - drug therapy Central Nervous System Stimulants - therapeutic use Child Discrimination (Psychology) - drug effects Dose-Response Relationship, Drug Double-Blind Method

Female Humans Male Methylphenidate - therapeutic use New York Reaction Time - drug effects Task Performance and Analysis

Associated Chemicals: Central Nervous System Stimulants (0) ; Methylphenidate (113-45-1)

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