Research article summary (published 3 Mar 2009):

The effect of naltrexone on amphetamine-induced conditioned place preference and locomotor behaviour in the rat.

Full Abstract

Whereas amphetamine and other psychostimulants primarily act on the dopamine system, there is also evidence that other neurotransmitter systems, such as the endogenous opioid system, modulate psychostimulant-induced effects. Several studies have investigated the role of opioid antagonists on cocaine-induced conditioned place preference (CPP), but there is limited information about the interaction with amphetamines. The aim of the present study was to investigate the effect of the opioid receptor antagonist, naltrexone (NTX) on the conditioning, expression and reinstatement of amphetamine-induced place preference. In addition, the effect of NTX on locomotor behaviour was measured during all sessions. During training, animals were conditioned with amphetamine (2 mg/kg) to induce place preference. In order to extinguish the conditioned behaviour, animals received saline for 12 days. Reinstatement of CPP was induced by a priming dose of amphetamine (0.5 mg/kg). The interaction of NTX and amphetamine was evaluated using three paradigms of CPP: with NTX (vehicle, 0.3, 1.0 and 3.0 mg/kg) administered either 30 minutes prior to amphetamine conditioning, or 30 minutes before the expression, or 30 minutes before the amphetamine priming to induce reinstatement. Naltrexone had no effect on the conditioning, the expression or the reinstatement induced by a priming dose of amphetamine. Further, NTX by itself did not induce place preference or place aversion. In contrast, NTX significantly attenuated the locomotor response to a priming dose of amphetamine without affecting general locomotor behaviour. The results suggest differences in opioid modulation of amphetamine-induced behaviours in the rat.

Author information

Author/s: Häggkvist, Jenny (J); Lindholm, Sara (S); Franck, Johan (J);

Affiliation: Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden. Jenny.Haggkvist(-atsign-)ki.se

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Addiction biology (Addict Biol), published in England. (Language: eng)

Reference: 2009-Jul; vol 14 (issue 3) : pp 260-9

Dates: Created 2009/06/15; Completed 2009/09/24;

PMID: 19298318, status: MEDLINE (last retrieval date: 9/24/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Amphetamine-Related Disorders - physiopathology Animals Brain - drug effects; physiopathology Central Nervous System Stimulants - toxicity Choice Behavior - drug effects; physiology Conditioning, Classical - drug effects; physiology Dextroamphetamine - toxicity Dose-Response Relationship, Drug Extinction, Psychological - drug effects; physiology

Extinction, Psychological - drug effects; physiology Male Motor Activity - drug effects; physiology Naltrexone - pharmacology Narcotic Antagonists - pharmacology Rats Rats, Wistar Receptors, Opioid - drug effects; physiology Social Environment

Associated Chemicals: Central Nervous System Stimulants (0) ; Narcotic Antagonists (0) ; Receptors, Opioid (0) ; Naltrexone (16590-41-3) ; Dextroamphetamine (51-64-9)

Related articles

These are the highest related articles currently in the database:

• Long-term voluntary D-amphetamine consumption and behavioral predictors for subsequent D-amphetamine addiction in rats. 5 Jan 2004
• Opioid receptors regulate the extinction of Pavlovian fear conditioning. 29 Nov 2003
• Effects of scopolamine on morphine-induced conditioned place preference in mice. 30 Aug 2007
• Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and reward. 20 Sep 2007
• Naltrexone blocks acquisition of voluntary ethanol intake in rats. 30 May 1997
• Stereological study of rat spleen following acute ethanol treatment. 29 Apr 2000
• Social reward-conditioned place preference: a model revealing an interaction between cocaine and social context rewards in rats. 19 Apr 2008
• Influence of chronic prenatal and postnatal administration of naltrexone in locomotor activity induced by morphine in mice. 30 Dec 1996
• Electroacupuncture reduces voluntary alcohol intake in alcohol-preferring rats via an opiate-sensitive mechanism. 15 Jul 2008
• Receptor-selective changes in mu-, delta- and kappa-opioid receptors after chronic naltrexone treatment in mice. 27 Feb 2003

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.