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| Research article summary (published 30 Mar 2009): |
Overexpression of DeltaFosB is associated with attenuated cocaine-induced suppression of saccharin intake in mice.
Full Abstract
Rodents suppress intake of saccharin when it is paired with a drug of abuse (Goudie, Dickins, & Thornton, 1978; Risinger & Boyce, 2002). By the authors' account, this phenomenon, referred to as reward comparison, is thought to be mediated by anticipation of the rewarding properties of the drug (P. S. Grigson, 1997; P. S. Grigson & C. S. Freet, 2000). Although a great deal has yet to be discovered regarding the neural basis of reward and addiction, it is known that overexpression of DeltaFosB is associated with an increase in drug sensitization and incentive. Given this, the authors reasoned that overexpression of DeltaFosB should also support greater drug-induced devaluation of a natural reward. To test this hypothesis, NSE-tTA x TetOp-DeltaFosB mice (Chen et al., 1998) with normal or overexpressed DeltaFosB in the striatum were given access to a saccharin cue and then injected with saline, 10 mg/kg cocaine, or 20 mg/kg cocaine. Contrary to the original prediction, overexpression of DeltaFosB was associated with attenuated cocaine-induced suppression of saccharin intake. It is hypothesized that elevation of DeltaFosB not only increases the reward value of drug, but the reward value of the saccharin cue as well. (c) 2009 APA, all rights reserved.
Author information
Author/s: Freet, Christopher S (CS); Steffen, Cathy (C); Nestler, Eric J (EJ); Grigson, Patricia S (PS);
Affiliation: Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. csf5(-atsign-)psu.edu
Grants: DA024519 (Agency:NIDA NIH HHS) ; DA09815 (Agency:NIDA NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal: Behavioral neuroscience (Behav Neurosci), published in United States. (Language: eng)
Reference: 2009-Apr; vol 123 (issue 2) : pp 397-407
Dates: Created 2009/03/31; Completed 2009/05/18;
PMID: 19331462, status: MEDLINE (last retrieval date: 5/18/2009, IMS Date: 18 May 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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