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| Research article summary (published 30 Mar 2009): |
Goal-directed responding is sensitive to lesions to the prelimbic cortex or basolateral nucleus of the amygdala but not to their disconnection.
Full Abstract
The current view of instrumental conditioning indicates that performance in the early stage of training is maintained by a representation of the outcome, as indexed by its sensitivity to changes in the value of the reward. In the present study, the authors tested the effects of a disconnection of the prelimbic cortex (PL) and the basolateral nucleus of the amygdale (BLA), using an asymmetric lesion procedure, to determine whether these structures interact sequentially as part of a corticolimbic system. In marked contrast to the effects of bilateral lesions of the PL or the BLA, which both altered rats' sensitivity to outcome devaluation, the disconnection of these 2 brain areas was without an effect on outcome devaluation. These results demonstrate that the PL and the BLA mediate different aspects of outcome representation in goal-directed responding. (c) 2009 APA, all rights reserved.
Author information
Author/s: Coutureau, Etienne (E); Marchand, Alain R (AR); Di Scala, Georges (G);
Affiliation: CNRS, Talence, France. e.coutureau(-atsign-)cnic.u-bordeaux1.fr
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Behavioral neuroscience (Behav Neurosci), published in United States. (Language: eng)
Reference: 2009-Apr; vol 123 (issue 2) : pp 443-8
Dates: Created 2009/03/31; Completed 2009/05/18;
PMID: 19331467, status: MEDLINE (last retrieval date: 5/18/2009, IMS Date: 18 May 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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