Research article summary (published 26 Mar 2009):

EGFR protein overexpression and gene copy number increases in oral tongue squamous cell carcinoma.

Full Abstract

New promising therapeutic agents targeting epidermal growth factor receptor (EGFR) have been developed although clinical information concerning EGFR status in oral tongue squamous cell carcinoma (OTSCC) is limited. We investigated EGFR protein expression and gene copy numbers in 78 pretreatment OTSCC paraffin samples. EGFR protein expression was found in all 78 tumours, of which 72% showed an intense staining. Fifty-four percent of the tumours had high (> or =four gene copies) EGFR gene copy numbers. EGFR gene copy number was significantly associated with EGFR protein expression (P=0.002). Pretreatment EGFR staining intensity tended to be associated with non-pathological complete remission after preoperative radiotherapy for Stage II OTSCC. No correlation was found between EGFR status and survival. EGFR FISH results were significantly (P=0.003) higher in more advanced tumours (Stages II, III and IV) than in the tumours in Stage I. Non-smokers exhibited a significantly higher EGFR gene copy number and protein overexpression in Stages I and II OTSCC than smokers (P=0.001, P=0.009). In conclusion, EGFR was found to be overexpressed in all OTSCCs making this cancer type interesting for exploring new therapeutic agents targeting the EGFR receptor.

Author information

Author/s: Ryott, Michael (M); Wangsa, Darawalee (D); Heselmeyer-Haddad, Kerstin (K); Lindholm, Johan (J); Elmberger, Göran (G); Auer, Gert (G); Lundqvist, Elisabeth Vall (EV); Ried, Thomas (T); Munck-Wikland, Eva (E);

Affiliation: Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Karolinska University Hospital, Stockholm S-17176, Sweden. michael.ryott(-atsign-)karolinska.se

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

Journal: European journal of cancer (Oxford, England : 1990) (Eur J Cancer), published in England. (Language: eng)

Reference: 2009-Jun; vol 45 (issue 9) : pp 1700-8

Dates: Created 2009/06/01; Completed 2009/07/07;

PMID: 19332367, status: MEDLINE (last retrieval date: 7/24/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aged Carcinoma, Squamous Cell - genetics; metabolism; pathology Female Gene Dosage Genes, erbB-1 Humans In Situ Hybridization, Fluorescence Male Middle Aged

Neoplasm Proteins - metabolism Neoplasm Staging Prognosis Radiotherapy, Adjuvant Receptor, Epidermal Growth Factor - metabolism Smoking - adverse effects; metabolism Tongue Neoplasms - genetics; metabolism; pathology; radiotherapy Treatment Outcome Tumor Markers, Biological - metabolism Young Adult

Associated Chemicals: Neoplasm Proteins (0) ; Tumor Markers, Biological (0) ; Receptor, Epidermal Growth Factor (EC 2.7.1.112) ; EGFR protein, human (EC 2.7.10.1)

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