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| Research article summary (published 30 Mar 2009): |
Tissue drug concentration determines whether fluorescence or absorption measurements are more sensitive in diffuse optical tomography of exogenous contrast agents.
Full Abstract
The measurement sensitivities of absorbing and fluorescing objects in tissue are compared to determine conditions for which fluorescence data are favorable over those derived from absorption. A simulated human breast volume was used to model the relative perturbation in boundary data caused by a deeply embedded anomaly containing elevated concentrations of theoretical exogenous contrast agents with absorption properties resembling lutetium texaphyrin (LuTex) and Indocyanine Green (ICG). Synthetic data were used to produce quantum yield values representing the transition between conditions favorable to fluorescence versus absorption imaging. The parameters explored include tumor-to-background contrast, background drug concentration, and excitation light filtering efficiency. Drug concentration in the background was the primary factor that determined which contrast mechanism provided the more sensitive measurements. Specifically, fluorescence measurements are favorable if background drug concentrations are below 135-200 nM for LuTex and 25-50 nM for ICG, while absorption measurements are more sensitive above these ranges.
Author information
Author/s: Davis, Scott C (SC); Pogue, Brian W (BW); Dehghani, Hamid (H); Paulsen, Keith D (KD);
Affiliation: Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA. Scott.C.Davis(-atsign-)dartmouth.edu
Grants: R01 CA109558 (Agency:NCI NIH HHS) ; R01 CA69544 (Agency:NCI NIH HHS) ; U54 CA105480 (Agency:NCI NIH HHS)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal: Applied optics (Appl Opt), published in United States. (Language: eng)
Reference: 2009-Apr; vol 48 (issue 10) : pp D262-72
Dates: Created 2009/04/02; Completed 2009/06/11; Revised 2009/10/16;
PMID: 19340118, status: MEDLINE (last retrieved date: 10/19/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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