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| Research article summary (published 30 Mar 2009): |
Cognitive deficits in amyotrophic lateral sclerosis evaluated by event-related potentials.
Full Abstract
OBJECTIVE: To determine the cognitive profiles in non-demented, relatively less handicapped patients with early-stage sporadic amyotrophic lateral sclerosis (ALS) by using neuropsychological tests, event-related potentials (ERPs) and clinical scale. METHODS: We recruited 19 patients with sporadic ALS (eight with limb-onset, 11 with bulbar-onset) and 19 controls. In addition to the mini-mental state examination and the Wechsler adult intelligence scale-revised, we assessed the frontal lobe function with Wisconsin card sorting test, Stroop test and trail making test. We used auditory 'oddball' counting paradigm for the ERPs under 20-channel electroencephalogram (EEG) recording. Global field power (GFP) was computed, and its peak amplitudes and latencies of N1/N2/P3 were determined. The results of ERP and neuropsychological tests were correlated with respiratory function and clinical scale. RESULTS: No global cognitive impairment except for subtle frontal dysfunction was detected, although N1/N2/P3 GFP latencies were significantly prolonged in ALS patients than in the controls. Vital capacity correlated with P3 GFP amplitude, and the relative bulbar functional rating scale correlated with P3 GFP latency. CONCLUSIONS: Our findings indicated the presence of sub-clinical cognitive deficits in non-demented, sporadic ALS patients. In addition, clinical sub-types and respiratory function dependently influenced cognitive function in patients with sporadic ALS. SIGNIFICANCE: ERP confirmed cognitive impairment in patients with sporadic ALS.
Author information
Author/s: Ogawa, Tomohiro (T); Tanaka, Hideaki (H); Hirata, Koichi (K);
Affiliation: Department of Neurology, Dokkyo Medical University, Kitakobayashi 880, Mibu, Tochigi 321-0293, Japan. tomo0317(-atsign-)krb.biglobe.ne.jp
Journal and publication information
Publication Type: Journal Article
Journal: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology (Clin Neurophysiol), published in Netherlands. (Language: eng)
Reference: 2009-Apr; vol 120 (issue 4) : pp 659-64
Dates: Created 2009/04/10; Completed 2009/04/30;
PMID: 19342291, status: MEDLINE (last retrieval date: 4/30/2009, IMS Date: 30 Apr 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
Comments and Corrections
CommentIn: Clin Neurophysiol. 2009 Apr;120(4):645-6. (PMID: 19286420)
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