Research article summary (published Apr 2009):

Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in mice.

Full Abstract

RATIONALE AND OBJECTIVE: Whether monoamine oxidase inhibitors (MAOIs) can be used to suppress the reinforcing effect of cocaine remains unknown. This study was undertaken to examine effects of a long-term dosing regimen with selective MAOIs on cocaine and food reward. MATERIALS AND METHODS: Since single dose of clorgyline (2 mg/kg), deprenyl (1 mg/kg), and pargyline (10 mg/kg) did not acutely affect mouse locomotor activity, these doses were chosen to treat the male C57BL/6j mice on a daily basis. RESULTS: Fourteen consecutive days of pretreatments with clorgyline, deprenyl, or pargyline (one injection per day) did not affect natural reward-supported operant behavior, since acquisition of the lever pressing responses for food pellets under an FR-1 protocol did not differ among these drug- and saline-treated mice. Likewise, 24 consecutive days of pretreatments with clorgyline did not alter acquisition of the cocaine (0.3 mg/kg per infusion)-supported operant responses under an FR-1 protocol. In contrast, 24 days of pretreatments with deprenyl and pargyline abolished the cocaine-supported operant responses under a similar protocol. Twenty-four days of clorgyline treatment enhanced serotonin contents in striatum, nucleus accumbens, and frontal cortex. Frontal cortical 3,4-dihydroxyphenylacetic acid and 5-hydroxyindoleacidic acid concentrations were decreased following 24 days of pretreatments with deprenyl and pargyline. These changes were not evident in mice pretreated with clorgyline. CONCLUSIONS: We suggest that long-term treatments with MAO-B inhibitors may decrease cocaine-supported operant responses in cocaine-naïve mice by selectively decreasing frontal cortical metabolism of dopamine and serotonin.

Author information

Author/s: Ho, Ming-Che (MC); Cherng, Chianfang G (CG); Tsai, Yen-Ping N (YP); Chiang, Chih-Yuan (CY); Chuang, Jia-Ying (JY); Kao, Shu-Fang (SF); Yu, Lung (L);

Affiliation: Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan, 70101, Republic of China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Psychopharmacology (Psychopharmacology (Berl)), published in Germany. (Language: eng)

Reference: 2009-Jul; vol 205 (issue 1) : pp 141-9

Dates: Created 2009/06/12; Completed 2009/09/02;

PMID: 19343328, status: MEDLINE (last retrieval date: 9/4/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

3,4-Dihydroxyphenylacetic Acid - metabolism Analysis of Variance Animals Behavior, Animal - drug effects Cocaine - pharmacology Conditioning, Operant - drug effects Dopamine - metabolism Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Drug Administration Schedule Feeding Behavior - drug effects

Feeding Behavior - drug effects Hydroxyindoleacetic Acid - metabolism Male Mice Mice, Inbred C57BL Monoamine Oxidase Inhibitors - pharmacology Motor Activity - drug effects Reinforcement Schedule Reward Serotonin - metabolism Time Factors

Associated Chemicals: Dopamine Uptake Inhibitors (0) ; Monoamine Oxidase Inhibitors (0) ; 3,4-Dihydroxyphenylacetic Acid (102-32-9) ; Cocaine (50-36-2) ; Serotonin (50-67-9) ; Hydroxyindoleacetic Acid (54-16-0)

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