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| Research article summary (published 30 Mar 2009): |
Rosette-forming glioneuronal tumor: report of a chiasmal-optic nerve example in neurofibromatosis type 1: special pathology report.
Full Abstract
OBJECTIVE: Rosette-forming glioneuronal tumor is a rare, rather recently described tumor featuring a highly distinctive, biphasic histological pattern, including a cytologically uniform neuronal component of Homer-Wright type pseudorosettes and an accompanying astrocytic element resembling pilocytic astrocytoma. Its occurrence in the posterior fossa and association with the fourth ventricle is stereotypical and a feature of all reported cases. CLINICAL PRESENTATION: In this article, we describe the first rosette-forming glioneuronal tumor arising outside this site, a histologically classic example involving the anterior visual pathway and associated with neurofibromatosis type 1. INTERVENTION: Genetic (fluorescent in situ hybridization) studies demonstrated no large deletion in either normal or neoplastic tissue, indicating that the genetic abnormality underlying neurofibromatosis type 1 in this patient is likely a very small deletion or point mutation. CONCLUSION: The relation of the tumor to the underlying neurofibromatosis type 1 cannot be assessed.
Author information
Author/s: Scheithauer, Bernd W (BW); Silva, Ana I (AI); Ketterling, Rhett P (RP); Pula, J H (JH); Lininger, James F (JF); Krinock, Mark J (MJ);
Affiliation: Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USA. scheithauer.bernd(-atsign-)mayo.edu
Journal and publication information
Publication Type: Case Reports; Journal Article
Journal: Neurosurgery (Neurosurgery), published in United States. (Language: eng)
Reference: 2009-Apr; vol 64 (issue 4) : pp E771-2; discussion E772
Dates: Created 2009/04/07; Completed 2009/07/23;
PMID: 19349806, status: MEDLINE (last retrieval date: 8/20/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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