Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages.

Full Abstract

The aloe ingredients responsible for physiological effects and the concentrations required to exert their biological activities are not fully understood. This study compares the anti-inflammatory effects of aloin and aloe-emodin with other polyphenols. Our results demonstrated that aloe-emodin dose-dependently inhibited inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production at 5-40 microM. In addition, the levels of cyclooxygenase-2 (COX-2) mRNA and prostaglandin E2 (PGE2) production were suppressed by 40 microM aloe-emodin. Aloin also suppressed the production of NO at 5-40 microM, although it did not suppress PGE2 production. The present results indicate that aloin and aloe-emodin possibly suppress the inflammatory responses by blocking iNOS and COX-2 mRNA expression. The anti-inflammatory effect of aloe-emodin was comparable to that of kaempferol and quercetin, indicating aloe-emodin as a possible key constituent responsible for the anti-inflammatory activity of aloe.

Author information

Author/s: Park, Mi-Young (MY); Kwon, Hoon-Jeong (HJ); Sung, Mi-Kyung (MK);

Affiliation: Department of Food and Nutrition, Sookmyung Women's University, Seoul, 140-742, Korea.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem), published in Japan. (Language: eng)

Reference: 2009-Apr; vol 73 (issue 4) : pp 828-32

Dates: Created 2009/04/24; Completed 2009/06/24;

PMID: 19352036, status: MEDLINE (last retrieval date: 6/24/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aloe - chemistry
Animals
Anthraquinones - pharmacology
Anti-Inflammatory Agents - pharmacology
Cell Line
Cell Survival - drug effects
Cyclooxygenase 2 - genetics
Dinoprostone - biosynthesis; secretion
Emodin - analogs & derivatives; pharmacology

Flavonols - pharmacology
Gene Expression Regulation, Enzymologic - drug effects
Isoflavones - pharmacology
Lipopolysaccharides - pharmacology
Macrophages - cytology; drug effects; metabolism
Mice
Nitric Oxide - biosynthesis; secretion
Nitric Oxide Synthase Type II - genetics
RNA, Messenger - genetics; metabolism

Associated Chemicals: Anthraquinones (0) ; Anti-Inflammatory Agents (0) ; Flavonols (0) ; Isoflavones (0) ; Lipopolysaccharides (0) ; RNA, Messenger (0) ; aloe emodin (0) ; Nitric Oxide (10102-43-9) ; Dinoprostone (363-24-6) ; Emodin (518-82-1) ; alloin (8015-61-0) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Cyclooxygenase 2 (EC 1.14.99.1)

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