Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.

Full Abstract

OBJECTIVES: Attention-deficit hyperactivity disorder (ADHD) is a highly heritable, common developmental disorder. Although a few confirmed associations have emerged from candidate gene studies, these have shown the same limitations that have become evident in the study of other complex diseases, often with inconsistent and nonreplicated results across different studies. METHODS: In this report, 27 ADHD candidate genes were explored in greater depth using high-density tag single nucleotide polymorphism (SNP) genotyping. Association with 557 SNPs was tested using the transmission disequilibrium test in 270 nuclear pedigrees selected from an ongoing ADHD genetic study that includes all disease subtypes. RESULTS: SNPs in seven genes including SLC1A3, SLC6A3, HTR4, ADRA1A, HTR2A, SNAP25, and COMT showed a nominal level of association with ADHD (P values <0.05), but none remained significant after a stringent correction for the total number of tests performed. CONCLUSION: The strongest signal emerged from SNPs in the promoter region (rs3808585) and in an intron (rs17426222, rs4732682, rs573514) of ADRA1A, all located within the same haplotype block. Some of the SNPs in HTR2A and COMT have already been reported by others, whereas other SNPs will need confirmation in independent samples.

Author information

Author/s: Elia, Josephine (J); Capasso, Mario (M); Zaheer, Zafar (Z); Lantieri, Francesca (F); Ambrosini, Paul (P); Berrettini, Wade (W); Devoto, Marcella (M); Hakonarson, Hakon (H);

Affiliation: Department of Pediatrics, Division of Pulmonary Medicine, Center for Applied Genomics, The University of Pennsylvania, Philadelphia, Pennsylvania, USA. elia(-atsign-)email.chop.edu

Grants: K23MH066275-01 (Agency:NIMH NIH HHS) ; UL1-RR-024134 (Agency:NCRR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Psychiatric genetics (Psychiatr Genet), published in England. (Language: eng)

Reference: 2009-Jun; vol 19 (issue 3) : pp 134-41

Dates: Created 2009/04/30; Completed 2009/06/26;

PMID: 19352218, status: MEDLINE (last retrieval date: 6/26/2009, IMS Date: 26 Jun 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Associated Chemicals: Receptors, Adrenergic, alpha-1 (0) ; adrenergic receptor alpha(1a) (0)

This article has not been indexed for related articles as yet, however you can still use the live related article search links below.

See 100+ related articles.

See a large map of 100+ related articles.