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| Research article summary (published 30 May 2009): |
Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community.
Full Abstract
OBJECTIVE: Hyperhomocysteinemia, neurohormonal activation, inflammation and altered fibrinolysis have been linked to atherothrombosis as well as to myocardial fibrosis and heart failure. Hence, we related a panel of biomarkers representing these pathways to plasma markers of collagen metabolism in a large community-based sample. METHODS: We related nine biomarkers representing select biologic pathways (independent variables: C-reactive protein, B-type natriuretic peptide, N-terminal proatrial natriuretic peptide, aldosterone, renin, fibrinogen, D-dimer, plasminogen activator inhibitor-1 and homocysteine) to three plasma markers of collagen turnover [dependent variables, separate models for each: aminoterminal propeptide of type III collagen, tissue inhibitor of metalloproteinases-1 and matrix metalloproteinase-9 (present versus absent)] in 921 Framingham Heart study participants (mean age 57 years; 58% women). Participants were separated a priori into those with left ventricular end-diastolic dimensions and wall thickness below sex-specific median values (referent group) and either measure at least 90th sex-specific percentile ('remodeled' group). We used stepwise multivariable regression analysis adjusting for cardiovascular risk factors to relate the panel of systemic biomarkers to the three biomarkers of collagen metabolism. RESULTS: Plasma homocysteine was positively related to all three markers of collagen metabolism in the remodeled group and to aminoterminal propeptide of type III collagen and tissue inhibitor of metalloproteinases-1 in the referent group. Plasminogen activator inhibitor-1 was positively related to aminoterminal propeptide of type III collagen and tissue inhibitor of metalloproteinases-1 in both groups, whereas the natriuretic peptides were associated positively with these collagen markers in the referent group. CONCLUSION: In our large community-based sample, plasma homocysteine and plasminogen activator inhibitor-1 were positively related to circulating collagen biomarkers, consistent with experimental studies implicating these pathways in cardiovascular collagen turnover.
Author information
Author/s: Joseph, Jacob (J); Pencina, Michael J (MJ); Wang, Thomas J (TJ); Hayes, Laura (L); Tofler, Geoffrey H (GH); Jacques, Paul (P); Selhub, Jacob (J); Levy, Daniel (D); D'Agostino, Ralph B (RB); Benjamin, Emelia J (EJ); Vasan, Ramachandran S (RS);
Affiliation: Cardiology Section (111), VA Boston Healthcare System, Boston, Massachusetts, USA. Jacob.joseph(-atsign-)bmc.org
Grants: HL080124 (Agency:NHLBI NIH HHS) ; K23-HL-074077 (Agency:NHLBI NIH HHS) ; K24-HL04334 (Agency:NHLBI NIH HHS) ; N01-HC-25195 (Agency:NHLBI NIH HHS) ; R01 HL67288 (Agency:NHLBI NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal: Journal of hypertension (J Hypertens), published in England. (Language: eng)
Reference: 2009-Jun; vol 27 (issue 6) : pp 1317-24
Dates: Created 2009/05/20; Completed 2009/08/25;
PMID: 19357531, status: MEDLINE (last retrieval date: 8/25/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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