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| Research article summary (published 13 Apr 2009): |
Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory.
Full Abstract
Previous data suggest that methylphenidate can have variable effects on different cognitive tasks both within and between individuals. This is thought to be underpinned by inverted U-shaped relationships between cognitive performance and dopaminergic activity in relatively separate fronto-striatal circuits and reflected by individual differences in trait impulsivity. Direct evidence for this is currently lacking. In this study, we demonstrate for the first time that therapeutic doses of oral methylphenidate administered to young healthy subjects result in different sized changes in D(2)/D(3) receptor availability in different regions of the human striatum and that the change in receptor availability within an individual subregion predicts cognitive performance on a particular task. Methylphenidate produced significantly different effects on reversal learning and spatial working memory tasks within individuals. Performance on the reversal learning task was predicted by the drug-induced change in D(2)/D(3) receptor availability in postcommissural caudate, measured using [(11)C]-raclopride radioligand PET imaging, whereas performance on the spatial working memory task was predicted by changes in receptor availability in the ventral striatum. Reversal learning performance was also predicted by subjects' trait impulsivity, such that the most impulsive individuals benefited more from methylphenidate, consistent with this drug's beneficial effects on cognition in attention deficit hyperactivity disorder.
Author information
Author/s: Clatworthy, Philip L (PL); Lewis, Simon J G (SJ); Brichard, Laurent (L); Hong, Young T (YT); Izquierdo, David (D); Clark, Luke (L); Cools, Roshan (R); Aigbirhio, Franklin I (FI); Baron, Jean-Claude (JC); Fryer, Timothy D (TD); Robbins, Trevor W (TW);
Affiliation: Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom.
Grants: (Agency:Medical Research Council) ; (Agency:Wellcome Trust)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)
Reference: 2009-Apr; vol 29 (issue 15) : pp 4690-6
Dates: Created 2009/04/16; Completed 2009/05/12;
PMID: 19369539, status: MEDLINE (last retrieval date: 5/12/2009, IMS Date: 12 May 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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