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| Research article summary (published 29 Apr 2009): |
Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile.
Full Abstract
Micropapillary lung adenocarcinoma (MPA) has been reported as an aggressive variant of adenocarcinoma, frequently manifesting at high stage with a poor prognosis. We analyzed the clinical and molecular profile of 15 primary MPAs for K-ras, EGFR, and BRAF mutations and performed fluorescence in situ hybridization for EGFR amplification. In our study, 11 (73%) of 15 MPAs harbored mutually exclusive mutations: 5 (33%) K-ras, 3 (20%) EGFR, and 3 (20%) BRAF. Mutations in all 3 genes occurred in patients with a smoking history and tumors with mucinous differentiation and secondary lepidic, acinar, and solid growth, suggesting that in a Western population, cytomorphologic correlation with genetic mutations is more unpredictable than in Japanese cohorts. We conclude that K-ras, EGFR, and BRAF mutations are disproportionately seen in adenocarcinomas of lung with a dominant micropapillary growth pattern compared with conventional adenocarcinoma in our institutional experience.
Author information
Author/s: De Oliveira Duarte Achcar, Rosane (R); Nikiforova, Marina N (MN); Yousem, Samuel A (SA);
Affiliation: Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213-2582, USA.
Journal and publication information
Publication Type: Journal Article
Journal: American journal of clinical pathology (Am J Clin Pathol), published in United States. (Language: eng)
Reference: 2009-May; vol 131 (issue 5) : pp 694-700
Dates: Created 2009/04/16; Completed 2009/04/28;
PMID: 19369630, status: MEDLINE (last retrieval date: 4/28/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
Comments and Corrections
CommentIn: Am J Clin Pathol. 2009 May;131(5):615-7. (PMID: 19369618)
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