Leukoaraiosis severity and list-learning in dementia.

Full Abstract

In patients with dementia, leukoaraiosis (LA) was hypothesized to result in differential patterns of impairment on a verbal serial list-learning test. Using a visual rating scale, 144 dementia patients with ischemic scores <4 were re-categorized as having mild (n = 73), moderate (n = 44), or severe LA (n = 27). Mild LA was predicted to be associated with an amnestic list-learning profile, while severe LA was predicted to be associated with a dysexecutive profile. List-learning performances were standardized to a group of healthy older adults (n = 24). Analyses were conducted on a set of four factors derived from the list-learning paradigm, as well as error scores. Data indicate that LA severity is an important marker for understanding list learning in dementia.

Author information

Author/s: Price, Catherine C (CC); Garrett, Kelly Davis (KD); Jefferson, Angela L (AL); Cosentino, Stephanie (S); Tanner, Jared J (JJ); Penney, Dana L (DL); Swenson, Rodney (R); Giovannetti, Tania (T); Bettcher, Brianne Magouirk (BM); Libon, David J (DJ);

Affiliation: Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, Florida, 32610, USA. cep23(-atsign-)phhp.ufl.edu

Grants: F32-AG021362 (Agency:NIA NIH HHS) ; K23-AG030962 (Agency:NIA NIH HHS) ; K23NS060660_01 (Agency:NINDS NIH HHS) ; P30-AG013846 (Agency:NIA NIH HHS) ; R03-AG026610 (Agency:NIA NIH HHS) ; R03-AG027480 (Agency:NIA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: The Clinical neuropsychologist (Clin Neuropsychol), published in England. (Language: eng)

Reference: 2009-Aug; vol 23 (issue 6) : pp 944-61

Dates: Created 2009/07/16; Completed 2009/10/07;

PMID: 19370451, status: MEDLINE (last retrieval date: 10/7/2009, IMS Date: )

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