Lability of neuronal lineage decisions is revealed by acute exposures to ethanol.

Full Abstract

Developing neurons pass through periods of sensitivity to environmental factors, e.g., alterations induced by ethanol are defined when the exposure occurs. We tested the hypothesis that timely episodic prenatal exposure to ethanol can change the lineage of cortical neurons. This study exploited mice in which many layer V neurons expressed a Thy1-YFPh transgene and endogenously fluoresced yellow. Fetuses were exposed to ethanol or saline on gestational day (G) 14 (when layer V neurons were generated) or on G 15 or 17 (when these layer V neurons were migrating). Fetuses dosed on G 14 exhibited an increased frequency of YFP+ neurons across cortex. This contrasted with a decreased frequency following ethanol exposure on G 17. Ethanol did not affect overall density of layer V neurons or their generation. Thus, the magnitude and valence of ethanol-induced changes in YFP+ neurons are time-dependent. Cell lineage is defined at the time of origin and the window of lability for this definition continues into the early post-mitotic (migratory) period. 2009 S. Karger AG, Basel.

Author information

Author/s: Miller, Michael W (MW); Hu, Huaiyu (H);

Affiliation: Department of Neuroscience and Physiology, State University of New York-Upstate Medical University, Syracuse, NY 13210, USA. millermw(-atsign-)upstate.edu

Grants: AA06916 (Agency:NIAAA NIH HHS) ; AA07568 (Agency:NIAAA NIH HHS) ; HD44011 (Agency:NICHD NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Developmental neuroscience (Dev Neurosci), published in Switzerland. (Language: eng)

Reference: 2009-; vol 31 (issue 1-2) : pp 50-7

Dates: Created 2009/04/17; Completed 2009/06/16;

PMID: 19372686, status: MEDLINE (last retrieved date: 6/16/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals
Antimetabolites - diagnostic use
Bromodeoxyuridine - diagnostic use
Cell Lineage - drug effects
Cell Movement - drug effects
Central Nervous System Depressants - blood; toxicity
Cerebral Cortex - cytology; drug effects
Ethanol - blood; toxicity
Female

Female
Fetal Alcohol Syndrome - pathology
Luminescent Proteins
Mice
Mice, Inbred C57BL
Mitosis - drug effects
Neurons - drug effects
Pregnancy
Pyramidal Cells - drug effects; physiology

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Antimetabolites (0) ; Central Nervous System Depressants (0) ; Luminescent Proteins (0) ; yellow fluorescent protein, mouse (0) ; Bromodeoxyuridine (59-14-3) ; Ethanol (64-17-5)

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