Augmentation of cocaine-sensitized dopamine release in the nucleus accumbens of adult mice following prenatal cocaine exposure.

Full Abstract

Behavioral changes in adult mice after prenatal exposure to cocaine have been identified. Mice exposed to cocaine in utero (40 or 20 mg/kg/day) and controls were given a sensitizing cocaine regimen (15 mg/kg every other day x 7 doses), withdrawn for 21 days, and challenged with 15 mg/kg cocaine. In vivo microdialysis for dopamine (DA), serotonin, and their metabolites in awake behaving mice on the first, seventh and challenge doses showed increased cocaine-stimulated DA release in the nucleus accumbens, which was significantly enhanced after prenatal cocaine exposure. This effect was not due to fetal malnutrition or changes in the total tissue DA content. Early developmental cocaine exposure may alter adaptation of brain reward systems to chronic psychostimulant exposure in adulthood. 2009 S. Karger AG, Basel.

Author information

Author/s: Malanga, C J (CJ); Ren, Jia-Qian (JQ); Guerriero, Réjean M (RM); Kosofsky, Barry E (BE);

Affiliation: Laboratory of Molecular and Developmental Neuroscience, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. malangacj(-atsign-)neurology.unc.edu

Grants: DA000354 (Agency:NIDA NIH HHS) ; DA008648 (Agency:NIDA NIH HHS) ; DA015429 (Agency:NIDA NIH HHS) ; K08 DA015429-05 (Agency:NIDA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Developmental neuroscience (Dev Neurosci), published in Switzerland. (Language: eng)

Reference: 2009-; vol 31 (issue 1-2) : pp 76-89

Dates: Created 2009/04/17; Completed 2009/06/16; Revised 2009/09/30;

PMID: 19372689, status: MEDLINE (last retrieval date: 10/1/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

3,4-Dihydroxyphenylacetic Acid - metabolism
Animals
Cocaine - pharmacology
Dopamine - metabolism
Dopamine Uptake Inhibitors - pharmacology
Female
Hydroxyindoleacetic Acid - metabolism

Mice
Microdialysis
Motor Activity - drug effects
Nucleus Accumbens - drug effects; metabolism
Pregnancy
Prenatal Exposure Delayed Effects - metabolism
Serotonin - metabolism

Associated Chemicals: Dopamine Uptake Inhibitors (0) ; 3,4-Dihydroxyphenylacetic Acid (102-32-9) ; Cocaine (50-36-2) ; Serotonin (50-67-9) ; Hydroxyindoleacetic Acid (54-16-0)

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