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| Research article summary (published 15 Apr 2009): |
Juvenile methylphenidate exposure and factors that influence incentive processing.
Full Abstract
Methylphenidate (MPH) is one of the few psychotropic agents approved for use in pediatric populations, underscoring the importance of elucidating any long-term consequences following exposure to this agent. Here, we examined the influence of several variables (i.e. age of assessment, age of exposure, sex, route of administration) on the effect of chronic low-dose MPH (2 mg/kg, twice daily) exposure on place conditioning to cocaine. Juvenile exposure to MPH, but not later exposure, resulted in aversions to cocaine-paired environments when assessed in young adult male rats, but not those entering adolescence. Juvenile MPH enhanced place preferences for cocaine-paired environments in female adolescent rats. The route of administration (i.p. injection or oral ingestion) did not produce enduring differential effects on behavior, and D-MPH was confirmed as the active enantiomer. These observations add to the growing literature on the enduring effects of MPH exposure, and highlight the need for more research in females. 2009 S. Karger AG, Basel.
Author information
Author/s: Brenhouse, Heather C (HC); Napierata, Lee (L); Kussmaul, Lucinda (L); Leussis, Melanie (M); Andersen, Susan L (SL);
Affiliation: Laboratory for Developmental Neuropsychopharmacology, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.
Grants: DA-015403 (Agency:NIDA NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal: Developmental neuroscience (Dev Neurosci), published in Switzerland. (Language: eng)
Reference: 2009-; vol 31 (issue 1-2) : pp 95-106
Dates: Created 2009/04/17; Completed 2009/06/16;
PMID: 19372691, status: MEDLINE (last retrieval date: 6/16/2009, IMS Date: 16 Jun 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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